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RPE use similar pathway to regulatory T cells to inhibit immune response
Retinal pigment epithelial (RPE) cells form an important part of the blood-retinal barrier that protects the neuronal cells responsible for sight. RPE cells are involved in innate and adaptive immune responses via expression of surface molecules and release of cytokines....
Phakic iris clip lenses and endothelial cell loss
This retrospective observational study included long-term results on endothelial cell losses in highly myopic eyes, which underwent phakic iris-clip lens implantations. Included in the analysis were 113 eyes with mean preoperative spherical equivalent (SEQ) of -14.67 +/- 5.15 Diopters (D)....
MicroRNA inhibits corneal neovascularisation
MicroRNAs (miR) are small non-coding RNA that target mRNA for destruction. MiR target about 30% of the protein coding genes and fine tune their expression. MiR have been shown to be involved in several cellular processes including cell cycle, tissue...
Diagnosis of amiodarone-associated optic neuropathy
Amiodarone is a widely used anti-arrhythmic drug. Several case reports describe optic neuropathy which has been linked to its use. This case series discusses the diagnosis of amiodarone-associated optic neuropathy (AAON) and its potential impact on cardiac therapy. The authors...
Autophagy in lens mitochondria loss
The lens consists of a monolayer of epithelial cells that overlies fibre cells that differentiate from epithelial cells at the equator. While developing, fibre cells need mitochondria to provide energy, as they mature they lose these and other organelles to...
Retrospective safety assessment of apraclonidine for diagnosis of Horner’s syndrome in children
Apraclonidine has been shown to reverse the anisocoria in Horner’s syndrome, with some reports of partial ptosis resolution. Side-effects of apraclonidine have been reported especially in children under six months old. The authors present a retrospective safety study of using...
Natural history of idiopathic intracranial hypertension depending on incidental or symptomatic presentation
The authors present a large retrospective review cohort of consecutive patients diagnosed or presumed idiopathic intracranial hypertension (IIH) over a three-year period at a single tertiary centre. Patients on medication with a known aetiology for IIH were excluded. The cohort...Théa Communication Skills online courses with 7 Category D Professional/Managerial CPD points
Théa have developed a series of Communications Skills courses in conjunction with a group of senior Ophthalmology Consultants who identified a gap in the existing training available in this key area.Nordic Pharma Announces CE Mark Approval for Lacrifill® Canalicular Gel, Paving the Way for European Launch
Nordic group B.V – an international pharmaceutical company operating as Nordic Pharma have received CE mark approval for Lacrifill®, a novel dry eye therapy. Lacrifill® is a cross-linked hyaluronic acid gel that temporarily blocks tear drainage by occluding the canalicular...
Keratoconus prevalence in astigmatic adolescents
The authors from Israel performed a cross-sectional study of 896,377 adolescents aged 16–20 years who underwent refraction and topography/tomography between 2011 and 2022. A total of 1886 (0.21%) were diagnosed with keratoconus with increasing astigmatism level being strongly associated with...
