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Randomisation, confounding & observational methods in ophthalmic epidemiology
Randomisation and confounding Understanding the relationship between an exposure and an outcome of interest is the central challenge in ophthalmic epidemiology. The exposure may be aetiological, taking the form of a putative risk biological factor, or therapeutic, in the form...Eyes on Rwanda: Lessons from an international ophthalmology experience
On the 26 February 2025, I travelled to Rwanda on the invitation of a former Belfast trainee, Michael Mikhail. Michael is now one of only two vitreoretinal (VR) surgeons in Rwanda, a country with a population of 14 million. Born...Could the sclera be key to glaucoma?
The glaucomas are a group of conditions characterised by optic neuropathy and associated visual field defects. Of these, chronic open-angle glaucoma (COAG) – diagnosed on the basis of progressive structural changes to the optic nerve head (ONH) and nerve fibre...Bovine pericardium scleral patch graft associated scleritis: Ahmed valve implant for pupillary block glaucoma
Processed bovine pericardium is a lyophilised collagen sheet used as a surgical armamentarium. It renders the material antigenically inert with minimal inflammation [1]. Sclera patch pericardium graft (Tutopatch) is a collagenous membrane derived from solvent preserved, irradiated bovine pericardium [2]...My Top Five: Social movements changing eyecare awareness
Throughout recent years, the rise of the digital age has allowed for social movements to receive far greater awareness than was ever deemed possible. As a result, significant attention has been drawn towards initiatives focusing on a range of health...Immunoglobulin G4-related ophthalmic disease – what is it? (Part 1)
Part 1: Epidemiology, classification, radiology, histopathology and associations (see Part 2 here) In this two-part series, Li Yen Goh reviews IgG4 disease and reminds us of diagnostic challenges faced. Introduction Immunoglobulin G4 (IgG4) disease is a recently recognised idiopathic systemic...The approach to angle-closure glaucoma
Further to my last article in Eye News (print issue) describing the diagnostic approaches to various clinical scenarios in glaucoma, the approach to angle-closure glaucoma (ACG), a situation terrifying for patient and registrar alike, will be discussed. Please refer to...
Capsular tension rings to reduce refractive shift
The study group aimed to determine whether the use of a capsular tension ring (CTR) can increase refractive stability in patients with implantation of two different trifocal intraocular lenses. This was a prospective, consecutive series of eyes which underwent refractive...
Practice patterns of uveal melanoma management with Iodine-125 brachytherapy
With the 2006 Collaborative Ocular Melanoma Study Group (COMS) study demonstrating no difference in survival outcomes for participants randomised to either iodine-125 brachytherapy or enucleation, the majority of primary uveal melanomas in the United States are now treated with brachytherapy....
