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MicroRNA mediate retinoblastoma signal transduction
MicroRNAs (miR) are small non-coding single-stranded RNA molecules, normally 22 nucleotides long. There is a large family of miR that control protein expression by binding to mRNAs, leading to their degradation. One important role of miR is in tumours where...
Akimba mice, a model of human diabetic retinopathy
Diabetic retinopathy (DR) is a major complication of diabetes and a growing problem as the systemic disease becomes more prevalent. DR develops insidiously from an asymptomatic form through to vascular damage that leads to oedema and breakdown of the blood-retinal...
B-scan ultrasonography
B-scan ultrasonography is commonly employed for the diagnosis and follow-up of ocular trauma. This retrospective study looked at the accuracy and predictive ability of B-scan ultrasonography following open globe repair. Of the 965 patients identified with open globe injuries at...
Early surgery for epiretinal membrane
This was a retrospective case review study in 120 consecutive patients with idiopathic epiretinal membrane. The average patient age was 72 years with a mean follow-up of 6.5 months. Inclusion criteria consisted of symptomatic patients with visual acuity of 1.0...
Resolution of mid-peripheral schisis in x-linked retinoschisis with the use of dorzolamide
X-linked retinoschisis (XLRS) is an early onset hereditary retinal dystrophy. It is caused by mutations of the RS1 gene. Common manifestations of XLRS are schitic lesions at the macula, as well as infero-temporal schisis. Carbonic anhydrase inhibitors have previously been...
Effect of laser wavelength on delivering effective burns through opaque lens using pattern scan laser
Panretinal photocoagulation (PRP) has been used in the treatment of various retinal disorders for many decades. Conventional single-spot lasers take quite some time to do with significantly higher pain, anxiety and photophobia when compared to the pattern scan laser (PSL)....
Visual fields and OCT in hydroxychloroquine retinopathy
It has been recommended that patients on hydroxychloroquine be monitored regularly for retinopathy. However, there has not been an agreement as to the best screening test for hydroxychloroquine toxicity, which may include visual fields (VF), fundus autofluorescence, spectral domain optical...
Cataract in patients with pseudoexfoliation syndrome
The authors present a prospective comparative study in 43 patients with (group 1) or without (group 2) pseudoexfoliation (PXF) undergoing cataract surgery. Anterior capsule samples were obtained in all patients and analysed for signs of apoptosis by using special staining...
Optical quality difference between monofocal and multifocal intraocular lenses
It is well known that multifocal intraocular lenses (IOLs) can generate more than one focus to restore distance and near vision, but patients may experience adverse optical phenomena such as decreased contrast sensitivity and induced glare or halos. The authors...
Phakic iris clip lenses and endothelial cell loss
This retrospective observational study included long-term results on endothelial cell losses in highly myopic eyes, which underwent phakic iris-clip lens implantations. Included in the analysis were 113 eyes with mean preoperative spherical equivalent (SEQ) of -14.67 +/- 5.15 Diopters (D)....
MicroRNA inhibits corneal neovascularisation
MicroRNAs (miR) are small non-coding RNA that target mRNA for destruction. MiR target about 30% of the protein coding genes and fine tune their expression. MiR have been shown to be involved in several cellular processes including cell cycle, tissue...
