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My Top Five: Promising gene therapies for ocular conditions
Gene therapy, a pivotal advancement in modern medicine, particularly shines in ophthalmology. By targeting defective genes with engineered vectors, this approach promises significant strides in treating inherited retinal diseases. This article reviews the top five gene therapies in late-stage trials,...My Top Five: Promising gene therapies for ocular conditions
Gene therapy, a pivotal advancement in modern medicine, particularly shines in ophthalmology. By targeting defective genes with engineered vectors, this approach promises significant strides in treating inherited retinal diseases. This article reviews the top five gene therapies in late-stage trials,...
Hereditary profile of retinal detachment
This review sought to clarify some of the heritable elements of rhegmatogenous retinal detachment (RRD). The familial element of RRD is well established, with the sibling recurrence risk ratio being 2.1 (Mitry and colleagues), and the parent-offspring recurrence risk ratio...
Transfected RPE cells inhibit AMD in rats
Age-related macular degeneration (AMD) is a leading cause of blindness in the elderly. Wet AMD is characterised by choroidal neovascularisation, new vessels into the retina, leading to leakage and tissue damage. Many proangiogenic factors particularly vascular endothelial growth factor (VEGF)...
Driving with retinitis pigmentosa
The authors present a study of 228 consecutive patients with a clinical or genetic diagnosis of retinitis pigmentosa. Data was collected prospectively between January 2012 and October 2022 in Perth, Australia. The study aimed to determine the proportion of patients...
Transcriptomic and regulatory gene associations in open angle glaucoma
The authors report a study utilising a publicly available whole exome sequencing dataset of 28 patients with primary open angle glaucoma (POAG) and seven healthy control patients, and a transcriptomic dataset from the trabecular meshwork of four POAG patients and...‘Getting a head start’: ways medical students can boost their chances of entering ophthalmology training
Ophthalmology is one of the most competitive medical specialities in the UK, with 3.74 applicants per place in 2018 [1]. Given the competitive nature of this highly specialised field, medical students who are interested in pursuing a career in ophthalmology...Ophthalmology Specialty Training 2024: What's different?
The 2024 intake for ophthalmology specialty training (OST) has undergone several significant changes in its approach towards candidate selection and assessment. This article provides a comparative analysis, detailing these new measures and comparing them against the previous year's standards. Our...Katie Piper and a host of stars mark World Sight Day 2025 with International Eye Care Charity Orbis
To celebrate World Sight Day, Orbis, the international eyecare charity, hosted an intimate breakfast event this morning at the historic St Pancras London Hotel, situated in King’s Cross. The gathering brought together high-profile people from the worlds of entertainment, fashion,...Dr William Mackenzie: a founding figure of modern ophthalmology
The author looks at the career of William Mackenzie and the important role he played in establishing the status of ophthalmology as a recognised medical speciality. There are certain individuals who, blessed with ability and means, are destined to leave...The interpretation and use of ultrasound biomicroscopy (part 1)
Ultrasound Biomicroscopy (UBM) has become increasingly important for the diagnosis of a variety of anterior segment pathologies. Most ophthalmologists are familiar with conventional B-scan ultrasonography techniques, which operate at lower sound frequencies (7.5 to 20MHz). UBM is an ultrasound technique...
