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The compendium to clinical evidence in DMO treatment

This review article summarises the current evidence base in the treatment options for diabetic macular oedema (DMO). The authors have included many real-world data studies that provided valuable insights into the optimal management of DMO. The authors argue that these...

Macular pigment in relatives of AMD patients

Blue light causes photo-oxidative retinal injury and macular pigment (MP), with lutein, zeaxanthin and mesozeaxanthin as the main components, as a filter that protects the macula from this damage. Previous studies indicated that low levels of macular pigment optical density...

Clinical predictors of proliferative sickle cell retinopathy

Sickle Cell Disease (SCD) is an inherited disorder resulting in production of Haemoglobin S (HbS), which aggregates in conditions of hypoxia, acidosis or hyperosmolarity. This leads to vascular stasis, thrombosis and ischaemia. The authors present a cross-sectional study (45 consecutive...

Is thrombolytic treatment warranted for central retinal artery occlusion?

Central retinal artery occlusion (CRAO) is a subtype of acute ischaemic stroke which results in severe visual loss. Acute CRAO is equivalent to a brain acute ischaemic stroke (AIS), as the obstruction of the central retinal artery (CRA) causes end-organ...

Review of chalazion treatment

Even though chalazion is a common eyelid lesion, there is lack of consensus on a treatment algorithm. Conservative management includes lid hygiene and warm compresses and, in some cases, steroid ointments for two to three weeks. More invasive options for...

Comprehensive review of inherited retinal diseases

The authors offer an up-to-date review of inherited retinal diseases (IRDs). In each section the authors discuss the molecular basis of disease, genotype and clinical manifestation. They also discuss the investigation findings and current evidence in the treatment of the...

Atopic dermatitis: Risk of glaucoma progression?

This population-based retrospective cohort study from December 5, 2003 to December 3, 2018 examined 528,469 patients with glaucoma with a diagnosis of atopic dermatitis (AD) based on diagnostic claim codes from the TriNetX Research Network, which contains real-time information on...

Long-term treatment for diabetic macular oedema

The authors set out to characterise anti-VEGF treatment patterns and long-term outcomes in patients with diabetic macular oedema. A retrospective analysis of over 190 thousand patients on the Intelligent Research in Sight registry was performed. Of these, 1236 eyes have...

How the thinking machine is transforming the retinal landscape

Regulatory approval of the first two therapeutic substances for the management of geographic atrophy (GA) secondary to age-related macular degeneration has been a major breakthrough. The authors explored the issue surrounding the lack of agreed therapeutic standards and diagnostic tools...

Smartphone use in adolescents and association with ocular symptoms and binocular issues

In this study, the proportion of ocular symptoms and binocular dysfunction was evaluated to determine their association with smartphone use on adolescents aged 10–19 years. This was a cross-sectional study of 123 participants (52% male, 48% female) with a mean...