Subretinal drusenoid deposits (SDD), originally termed ‘reticular pseudo-drusen’, have recently been identified by histology and optical coherence tomography (OCT) as aggregations located in the subretinal rather than the sub retinal pigment epithelium (RPE) space. These deposits affect the amount of light reaching the deeper layers. Spectral domain OCT (SD-OCT) shows disruption of inner segment / outer segment (IS / OS) band, which has been suggested to carry prognostic implications. This study evaluates the correlation between light sensitivity and SDD as measured with microperimetry. Twenty-one consecutive patients / eyes with SDD only were included in the study along with twenty patients / eyes in the control group. The control group had early macular degeneration in at least one eye. In all cases best corrected visual acuity (BCVA), colour fundus photography, fundus autofluorescence and SD-OCT with integrated microperimetry were performed. The mean BCVA in the SDD group was 0.18±0.14 LogMAR and the mean BCVA in the control group was 0.16±0.15 LogMAR. In eyes with SDD, the overall mean light sensitivity in the central macula (4.21± 2.46 dB) was significantly reduced when compared to the control group (6.81±2.12 dB). Correlation between BCVA and mean light sensitivity in the central 7x7mm square was low in the SDD group (Pearson’s rho = 0.4, p=0.01), while it was good in the control group (Pearson’s rho = 0.7, p=0.001).

Microperimetry of subretinal drusenoid deposits.
Forte R, Cennamo G, Crecchio G, Cennamo G.
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Bheemanagouda Patil

Waikato Hospital, Hamilton, New Zealand

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