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Pharma chameleon

3 April 2024 | | EYE - General
One morning in September ’95, about a month into my first house job on the South Coast of England, I emerged from the ridiculously early ward round on the coronary care unit feeling a bit dazed and therefore headed off...

Large language models in ophthalmology

3 October 2024 | | EYE - General
Traditional artificial intelligence (AI) models typically require large amounts of labelled data for training. For example, to develop a model capable of detecting macular pathologies on optical coherence tomography scans, thousands of scans would need to be manually labelled by...

Management of a giant pigment epithelium detachment with transition from half- to full-dose aflibercept

2 March 2026 | | EYE - Imaging, EYE - Vitreo-Retinal
This case report describes the management of a giant pigment epithelial detachment (PED) in neovascular age-related macular degeneration (nAMD) using half-dose aflibercept. An 80-year-old woman presented with a huge PED (maximum height 1338µm) and multiple risk factors for retinal pigment...

Ultra-widefield imaging in glaucoma: Documenting hypotony-related choroidal effusions after microshunt surgery

3 April 2026 | | EYE - Glaucoma, EYE - Imaging
Ultra-widefield (UWF) imaging provides extended visualisation of the posterior segment beyond the traditional 30–50° field of view. It captures a broad view of the posterior pole and periphery in a single, quick, non-mydriatic acquisition. While its role in diabetic retinopathy...

Broadening of treatment options for potentially blinding retinal conditions

2 August 2022 | | EYE - General
Rod McNeil provides an update on a promising bispecific antibody recently approved for treatment of neovascular age-related macular degeneration (nAMD) and diabetic macular oedema (DMO) and considers emerging developments in biosimilars to established anti-vascular endothelial growth factor (anti-VEGF) therapies, including...

Vitreomacular traction and full thickness macular hole

1 December 2017 | | EYE - Vitreo-Retinal, EYE - Imaging
Clinical scenario: A 64-year-old lady presented to the clinic with a few weeks history of sudden onset of metamorphopsia, central blur and reduced vision in her right eye. The ocular examination and ocular coherence tomography confirmed right eye focal vitreomacular...

Strabismus in thyroid eye disease

1 April 2017 | | EYE - Paediatrics, EYE - Strabismus
Pathogenesis Thyroid eye disease (TED) is an auto-immune condition, in the initial phase there is lymphocytic infiltration and oedema of the extraocular muscles with deposition of glycosaminoglycans and hyaluronic acid and adipogenesis, which can lead to an increase in the...

Poppers retinopathy: What is it and how do we treat it?

2 June 2025 | | EYE - Vitreo-Retinal
Poppers retinopathy is a relatively unknown phenomenon which afflicts users of poppers but should be considered as a differential in sudden-onset or sub-acute visual acuity loss – particularly in patients with a history of recreational drug use. Raising awareness of...

Principles of contact lens fitting in keratoconus

1 December 2015 | | EYE - Cataract, EYE - Refractive
Keratoconus is an ectatic condition of the cornea characterised by progressive conical distortion with irregular astigmatism, myopia and apical protrusion. Most cases progress slowly resulting in varying degrees of myopic astigmatism. Management of keratoconus includes spectacles, soft contact lenses, a...

An eye on novel anti-cancer agents: an evidence-based approach to external eye assessment

5 April 2022 | | EYE - Cornea, EYE - General
Novel anti-cancer therapies have led to significant advancement in cancer treatment, however, they can be associated with external eye complications. It is important to be mindful of such adverse effects during assessment of patients enrolled in clinical trials. Annually, approximately...

From paper to digital: Real lessons for a sustainable NHS digital future

19 February 2026 | | EYE - General
Portsmouth's OpenEyes implementation reveals why healthcare digital transformation needs honest evaluation, proper clinical leadership resourcing and realistic expectations about technology efficiency promises. Like many eye departments across the NHS, we at Portsmouth were drowning in paper. Notes went missing, handwriting...

Hot debates in medical retina and imaging: Perspectives from the Controversies in Ophthalmology 2020 virtual conference

5 August 2020 | | EYE - Vitreo-Retinal, EYE - Imaging, EYE - General
Controversies in medical retina and imaging were debated during the Controversies in Ophthalmology 2020 virtual conference held during two mid-day scientific sessions on 27 and 28 March 2020. The author recounts key perspectives and presents viewpoint recommendations from the Vision...