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OCTA in diabetic macular oedema treated with intravitreal aflibercept (DOCTA Study)

Central vision loss due to diabetic macular oedema (DME) can be attributed not only to presence of the macular oedema itself but also, in some cases, to alterations of the foveal avascular zone (FAZ). The DOCTA trial was a longitudinal,...

Early vitrectomy for endophthalmitis offers hope to patients

A Phase 2 feasibility study published today in the prestigious Nature Communications Medicine journal has shown that early vitrectomy surgery treatment for acute endophthalmitis can be potentially more beneficial to patients’ vision compared with the current antibiotic-first approach. This is...

Atlas of Clinical and Surgical Orbital Anatomy (Third Edition)

This textbook highlights in its preface to the third edition that considerable research has been undertaken in the fields of orbital and periorbital anatomy since 1994 (first edition) and 2011 (second edition). Various topics have been elucidated, such as the...

Effect of minor trauma in eyes with previously undiagnosed angioid streaks

Angioid streaks (AS) may be associated with pseudoxanthoma elasticum (PXE), Paget’s disease, haemoglobulinopathies, Ehlers-Danlos Syndrome or abetalipoproteinaemia. Histopathology showed retinal pigment epithelium (RPE) and choriocapillaris loss, elastic fibre degeneration, calcium deposition, active choroidal neovascular membrane (CNVM) and vascular endothelial growth...

Shafi Balal on predicting keratoconus progression

In this interview, section editors Nima Ghadiri and Arun James Thirunavukarasu ask Ophthalmic Surgeon and NIHR Doctoral Fellow Shafi Balal about the development of his AI model for predicting keratoconus progression risk, with the longer-term objective of using AI on...

Somatostatin protects retinal pericytes

Diabetic retinopathy (DR) is a complication of diabetes, caused by high blood sugar levels damaging the retinal microvasculature. Mechanisms, such as oxidative stress and deposition of advanced glycation end products, leads to glial cell activation and neuronal apoptosis. Pericytes, contractile...

A case presentation of morning glory disc anomaly and peripapillary staphyloma

The purpose of this paper is to present a case of an 18-month-old girl initially presenting with strabismus. Fixation of the affected eye was intermittent with a relative afferent pupillary defect. A fundus photography of the affected left eye showed...

Comparison of bupivacaine injection vs. mini-tenotomy for small angle deviations

Bupivacaine hydrochloride is an aminoacyltype local anaesthetic. Injection into extraocular muscles elicits a myotoxic response destroying striated muscle fibres but sparing satellite cells, nerves and vessels. Preserved satellite cells proliferate to form new muscle fibres, causing muscle hypertrophy and greater...

Understanding optic nerve head pericytes and glaucoma

The authors provide a comprehensive review of the current understanding of pericytes in the optic nerve head (ONH). Key points include: (1) Pericytes are contractile mural cells that play crucial roles in regulating blood flow, maintaining the blood-brain / blood-retinal...

Brain abnormality as risk factor for consecutive exotropia

The authors evaluated and compared the cerebral MRI findings in operated infantile esotropia cases with and without consecutive exotropia. This was a retrospective study of 28 patients. Group 1 had 17 cases of consecutive exotropia with a mean follow-up of...

REPORT: American-European Congress of Ophthalmic Surgery (AECOS) European Symposium

David Shahnazaryan, Consultant Ophthalmologist, London, UK and Radhika Rampat, Consultant Ophthalmologist, London, UK, report from the AECOS Symposium in Antwerp, Belgium (June 10-12).

CHEC achieves Investors in People status

CHEC, one of the largest providers of community-based ophthalmology services in the UK, has achieved Investors in People status, with its company values and culture pinpointed as being fundamental to the company’s success.