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Differential inhibition of EAU by CTLA4 and IL-6
Cytotoxic T lymphocyte antigen-4 (CTLA4) binds both CD80 and Cd86 and inhibits T lymphocyte activation via CD28. Il-6 is a pleiotropic cytokine that has been associated with many autoimmune conditions including uveitis. Blockade of these molecules by either CTLA4-Ig, a...
The effect of caffeine on pupil size and accommodation
Twenty-two young and healthy participants were recruited in this study. The authors showed that pupil size increased as a result of caffeine consumption. A more stable (lower variability of accommodation) accommodative response (AR) was induced by caffeine intake, whereas the...
Tocilizumab in Graves’ orbitopathy
This prospective European study looks at the response to tocilizumab in corticosteroid-resistant disease. Tocilizumab (TCZ) is a monoclonal antibody that competitively inhibits IL-6 binding to its receptor. Unlike teprotumumab, the advantage of TCZ is that it is already used within...Life’s rich tapestry
Have you ever watched someone cross-stitch, or do needle-point? I recently had the joy of observing my teenage daughter create such an artwork. She separated all the threads into the various colours, and then started to follow the instructions carefully....Navigating the retina: the nitty-gritty of slit-lamp fundus examination
The slit-lamp fundus examination can be a difficult and disorientating task for beginners due to the retina being viewed in a non-anatomical orientation, the small area of retina illuminated, and the counterintuitive technique of the examination. This article provides a...IN FOCUS - VISION 2020 LINKS Programme: the contribution of health partnerships to reduction in blindness worldwide
As other articles in this series (IN FOCUS Apr 2020) demonstrate, the year 2020 is highly significant in the eye care field. Naming a global initiative ‘VISION 2020: The Right to Sight’ in 1999 was a daring way to focus...
Dilate or not in subconjunctival haemorrhage?
There is often surprisingly little evidence in common clinical conditions. Spontaneous non-traumatic subconjunctival haemorrhage (SCH) is frequently encountered in emergency and walk-in clinic visits. In some centres, a dilated fundus exam is performed to exclude retinal pathology. This retrospective study...
