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OCT in peripheral corneal thinning
This small retrospective study used high resolution optical coherence tomography (OCT) Heidelberg Spectralis to identify features which could determine the underlying aetiology of peripheral corneal thinning. Ten patients were included; five with diagnoses of degenerative peripheral thinning; Terrien’s marginal degeneration...
RTP801 as a neuroprotective and axon regenerative treatment
This paper describes the neuroprotective and axon regenerative effects of siRTP801, which is a translatable small-interfering RNA (siRNA) targeting mTOR negative regulator; RTP801, through in-vivo and in-vitro models. In-vivo studies involved an optic nerve crush rat model with intravitreal injections...
Bioengineered human tissue
This is a literature review of the current status of tissue engineering related to ocular and oculoplastic reconstructive surgery. The authors describe the process of bioengineering for tissue reconstruction. The aim is to reproduce functional tissue by the use of...
A novel computerised portable pupillometer detects and quantifies relative afferent pupillary defect
We have all had referrals from A&E telling us that a patient can’t see out of one eye. Sleepily we may ask “Is there an relative afferent pupillary defect (RAPD)?” to evaluate the seriousness of the presentation. The response is...
LASEK with mitomycin C to correct myopia in thin corneas
This study evaluated the long-term outcomes of laser-assisted subepithelial keratomileusis (LASEK) with intraoperative use of mitomycin C (MMC) performed on thin corneas for the correction of myopia. MMC modulates the corneal wound healing response in surface healing, thus reducing the...
Ovarian hormones drive onset of Sjogren’s disease in mice
Sjogren’s syndrome (SS) is a debilitating, sight-threatening, systemic autoimmune disease with no effective treatment available. SS is characterised by lacrimal gland lymphocytic infiltration and epithelial cell death, as well as by the presence of serum autoantibodies. Patients have severe dry...
RAPD in glaucoma screening
A study was conducted to investigate the relative afferent pupillary defect (RAPD) by swinging flashlight as a potentially useful screening test for glaucomatous optic neuropathy. The authors recruited 107 subjects with or without glaucoma from a clinic population. A medical...
Using frequency doubling technology perimetry to identify Alzheimer’s disease early
Alzheimer’s disease is widely reported to be associated with deficits in visual function. Visual disturbances include impaired stereopsis, contrast sensitivity and motion detection. Deficits specific to the magnocellular pathway (MGC) have been identified in Alzheimer’s disease. This article compares the...
Comparison of ketorolac 0.4% and nepafenac 0.1% for the prevention of CMO after phacoemulsification
This is a prospective randomised clinical trial study including patients older than 40 years with age related cataract and normal ophthalmic examination. The patients are randomised into three different groups and the objective of the study is to compare the...
Task shifting for eye care in Eastern Africa
More than eight million people suffer with trichiasis due to trachoma globally, but less than 160,000 receive surgery per year even though “S” is a key aspect of the elimination of blindness due to trachoma as part of the WHO...
How does low-concentration atropine reduce progression of myopia?
This is a double-blind, randomised, placebo-controlled trial evaluating the effects of low-concentration atropine (0.05%, 0.025%, 0.01%) on ocular biometrics of myopic children. The aim is to determine what aspect of ocular biometrics low-concentration atropine influenced in reducing the progression of...
