Does methanol poisoning require ophthalmic investigation?
2 February 2024
| Claire Howard
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EYE - Neuro-ophthalmology
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Methanol poisoning, acute poisoning, case series, ocular findings, outbreak
The authors report a case series of 21 patients (41 eyes) diagnosed with acute methanol poisoning following an outbreak in Tunisia in 2020. All patients underwent a complete ophthalmological examination including visual fields, colour vision test and optical coherence tomography...
Ocular manifestations of Whipple’s disease
2 February 2024
| Lucy Osborne
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EYE - Vitreo-Retinal
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Granulomatous uveitis, Whipple’s disease, infectious uveitis, ocular infection, tropheryma whipplei
In this retrospective review of 217 patients with Whipple’s disease (WD), the authors reviewed the presentations of those with ocular manifestations. Ocular signs of WD are under recognised, frequently resulting in misdiagnosis and mismanagement. Mayo Data Explorer, a Mayo Clinic...
Bromfenac versus betamethasone in diabetic macular oedema
31 October 2023
| Kurt Spiteri Cornish
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EYE - Vitreo-Retinal
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Diabetic macular edema, betamethasone, bromfenac, central subfield thickness, intraocular pressure
This is a randomised, prospective, single-centre trial in patients diagnosed with diabetic macular oedema (DMO) with central subfield thickness (CST) of 250-500µm, who refused anti-VEGF treatment. Nineteen eyes of 19 patients were randomised to bromfenac (BF) or betamethasone (BM) drops,...
Rare presentation of giant cell arteritis in Chinese subjects
1 September 2023
| Claire Howard
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EYE - Neuro-ophthalmology
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non-arteritic anterior ischaemic optic neuropathy, Chinese, central retinal artery occlusion, Giant cell arteritis, ocular ischaemic syndrome, posterior ischaemic optic neuropathy
Only a few case reports of biopsy-proven GCA (BpGCA)-associated vision loss in Chinese subjects have been published. This paper presents three elderly Chinese subjects with BpGCA who presented with vision loss. A search of the literature was also conducted to...
Glaucoma medications and ocular surface disease
3 August 2023
| Su Young
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EYE - Glaucoma
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Drug allergy, OSD, drug toxicity, drug-induced cicatricial keratitis, dry eye, glaucoma medications, ocular surface disease
This literature review examined ocular surface disease (OSD) associated with glaucoma medication. The authors examined the prevalence of features and management guidelines glaucoma medication associated OSD. Fifty-eight articles published within the past five years are included in this review and...
Ocular hypertension following intravitreal steroid injections: a comparative study between triamcinolone-acetonide and dexamethasone-implant
3 April 2023
| Sofia Rokerya
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EYE - Vitreo-Retinal
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Dexamethasone-implant, Glaucoma, Intravitreal steroid-induced ocular hypertension, Risk factors for steroid-induced ocular hypertension, Triamcinolone-acetonide
This was a retrospective observational study of steroid response following 1549 intravitreal steroid (TA and Dex) injections. One thousand and seventy-five eyes of 897 patients were reviewed. Glaucoma patients, glaucoma suspects, uveitis, trauma, and cases with less than one month...
RCT review of surgery for open angle glaucoma
1 December 2022
| Su Young
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EYE - Glaucoma
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Intraocular pressure, Open angle glaucoma, meta-analysis, microstent, phacoemulsification
This systematic review and meta-analysis examined eight randomised controlled trials (RCTs) to compare the intraocular pressure (IOP) reducing effect of three types of microstent implantation (Hydrus, iStent, CyPass) combined with phacoemulsification versus phacoemulsification alone for patients with open-angle glaucoma (OAG)...
Inflammation and microvascular changes in diabetic retinopathy
1 February 2022
| Kurt Spiteri Cornish
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EYE - Vitreo-Retinal
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Aqueous flare, diabetes mellitus, diabetic retinal neuropathy, diabetic retinopathy, intraocular inflammation, neuroinflammation
Studies have shown that neurodegeneration and inflammation in the retina start early in diabetic retinopathy (DR) and can be present before the latter is clinically evident. The aim of this retrospective review of 99 diabetic patients was to evaluate retinal...
ROPPVAL Syndrome as a differential diagnosis to optic neuritis
1 December 2021
| Claire Howard
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EYE - Neuro-ophthalmology
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Photophobia, ROPPVAL, headache, migraine, optic neuritis, retro-ocular pain
Optic neuritis (ON) is a common cause of visual loss in young patients. Patients with eye pain and ipsilateral visual loss are often referred into neuro-ophthalmology clinics with a possible diagnosis of ON. In 2018 Jefferis et al. reported a...
Clinical outcomes of a supplementary sulcus IOL
1 October 2021
| Ed Rule
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EYE - Cataract, EYE - Refractive
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Dysphotopsia, Pigment deposits, Presbyopia correction, Rayner sulcoflex, Supplementary intraocular lens, implantation
In this retrospective study, the authors examined 31 eyes of 20 patients who had received a supplementary trifocal sulcus IOL in addition to a ‘bag-in-the-lens’ IOL. Implantation of a ‘bag-in-the-lens’ IOL requires the creation of anterior and posterior capsulotomies, followed...
A pulsatile pump in the TM, a new concept in trabecular outflow research
1 October 2021
| Zhihang Cheng
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EYE - Glaucoma
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Aqueous outflow pump, Elastance, Glaucoma, Intraocular pressure regulation, Pulsatile aqueous outflow, Schlemm's canal valves
This is a research article where the authors propose a new model in conceptualising the mechanisms involved in the aqueous outflow at the trabecular meshwork (TM). The authors demonstrated evidence of a pump within the Schlemm’s canal. A pulse generated...
The effects of ab-interno XEN gel implantation on postural IOP elevations
4 August 2021
| Su Young
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EYE - Glaucoma
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Xen gel implant, glaucoma, intraocular pressure, posture, rebound tonometry
The study involved 18 patients with XEN gel implants, 30 patients who had trabeculectomy, and 30 medically managed glaucoma patients. All patients in XEN gel implant and trabeculectomy groups had at least 11 months of follow-up following successful surgery resulting...
