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Amyotrophic lateral sclerosis (ALS): what happens to eye movements?
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder of upper motor neurons of the corticospinal tract and lower motor neurons in brainstem nuclei and the anterior horn of the spinal cord. Limited literature is available on abnormal ocular movements in...
Could internuclear ophthalmoplegia aid differential diagnosis in demyelinating conditions?
The authors present a retrospective review of individuals diagnosed with either neuromyelitis optica spectrum disorder (NMOSD) or multiple sclerosis (MS). The aim of the study was to assess the prevalence of internuclear ophthalmoplegia (INO) in both groups over a 10-year...
Can a dose scale be calculated for the modified Harado-Ito procedure?
The aim of this study was to review the surgical outcomes of the Fells modified Harado-Ito procedure using a dose scale approach with long-term follow-up, and to evaluate the relationship between preoperative factors and final outcome. This was a retrospective...
Does paediatric rhegmatogenous retinal detachment (RRD) obey Lincoff’s rule (LR)?
This was a retrospective study where 98 paediatric patients with RRD were identified through surgery records. Forty case sheets with complete record of ocular examination and surgical findings were analysed. Visible or suspected preoperative retinal break identified using the LR...
Can coenzyme Q10 have a protective role in ethambutol-induced retinal ganglion cell toxicity
Tuberculosis (TB) is one of the most prevalent infectious diseases, especially in developing or low- income countries. Ethambutol is a widely used drug to treat TB. Ethambutol can cause visual disturbance including ethambutol toxic optic neuropathy (ETON). ETON is one...
Sub-clinical detection methods in multiple sclerosis
Visually symptomatic multiple sclerosis (MS) provides only part of the required information to assist in understanding the disease. Recently, researchers have concentrated their efforts on diagnosing MS cases in the subclinical period. The aim of this paper was to assess...
Unilateral cataract extraction outcomes in older children compared to two studies with younger cohorts
The authors present a retrospective study of children undergoing cataract surgery between the ages of two and seven-years-old at one centre, over a 24-year period. Data including demographics, ocular history, ophthalmic findings, operative reports, adverse events, and record of re-operations...
How common are ocular motor cranial nerve palsies following TBI?
This retrospective cohort study aimed to report the incidence of ocular cranial nerve palsy as a result of traumatic brain injury (TBI). Patients were identified using an insurance database using codes from the International Classification of Disease 9th and 10th...
PRPF31-related retinitis pigmentosa and asymptomatic carriers
The authors present a study of 21 patients with variants in the PRPF31 gene classified as pathogenic or likely pathogenic. These variants are caused by autosomal dominant retinitis pigmentosa (RP-11). Between January 2020 and November 2021 patients underwent tests of...
What are the features of facial nerve palsies in children?
The aim if this study was to report ophthalmic related findings and complications in children with facial palsy. Medical records from a tertiary centre were retrospectively searched for children 16 years and under with a diagnosis of facial palsy, over...
Could idebenone by the solution for treating dominant optic atrophy?
Dominant optic atrophy (DOA) is a disease of the retinal ganglion cells, with no current treatment options. In most cases, DOA is caused by a mutation in the OPA1 gene. The aim of this study was to evaluate the effect...
