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Hyper reflective foci (HRF) on OCT in diabetic retinopathy
This study investigated the presence of hyper reflective foci (HRF) in asymptomatic patients affected by type 1 or type 2 diabetes, separately, without clinically significant diabetic macular oedema and visual impairment. In total 71 eyes with non-proliferative diabetic retinopathy were...
Coeliac disease and anterior scleritis
The authors present an interesting case report of recurrent anterior scleritis. Circulating IgA and IgG auto-antibodies directed against tissue transglutaminase, endomisium and gliadin are frequently elevated in patients with coeliac disease. The classic symptoms remain chronic diarrhoea, malabsorption syndromes and...My Top Five: Key insights from recent research into uveitis in adults
Uveitis, characterised by inflammation of the uvea – the eye’s middle layer comprising the iris, ciliary body, and choroid – remains a leading cause of visual impairment worldwide [1]. It primarily affects adults aged 20–50 years. Untreated uveitis may cause...SOS (Simplified Ophthalmic Statistics) Part 2: How to summarise your data and why it’s a good idea to do so
Studies involve capturing data. Statistical techniques allow data to be used to answer important research questions. A case series may have data on a handful of subjects but we are now entering the Big Data arena where datasets can be...
OCT in proliferative diabetic retinopathy
This report set out to describe the anatomical relationships between retinal neovascular complexes (NVC), the posterior vitreous, and the vitreoretinal interface in patients with proliferative diabetic retinopathy using spectral domain OCT. The following was recorded for each NVC 1) posterior...
Transcriptomic analysis of ocular tissues
Transcriptomics is defined as the analysis of the complete set of RNA transcripts present in a cell under different circumstances, quiescent versus challenge, by microarray analysis. Comparison of transcriptomes identifies genes that are differentially expressed in different cell populations under...
Retinal ischaemia on OCTA and diabetic retinopathy grade
The authors quite rightly point out that quantification of retinal ischaemia has the potential to serve as a biomarker for diabetic retinopathy disease progression. They set out to investigate the relationship between area of ischaemia on a swept source OCTA...
Can a dose scale be calculated for the modified Harado-Ito procedure?
The aim of this study was to review the surgical outcomes of the Fells modified Harado-Ito procedure using a dose scale approach with long-term follow-up, and to evaluate the relationship between preoperative factors and final outcome. This was a retrospective...
Comparison of thrombolysis and conservative management in acute retinal ischaemia
The authors present a retrospective cohort study of individuals presenting with acute, painless, monocular vision loss and diagnosed with acute retinal ischaemia. Reasons for exclusion were iatrogenic aetiology, transient vision loss, missing initial visual acuity data, more than 16 hours...
