Sub-clinical detection methods in multiple sclerosis
3 April 2023
| Claire Howard
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EYE - Neuro-ophthalmology
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Subclinical multiple sclerosis, axonal degeneration, frequency-doubling perimetry, optic neuritis, optical coherence tomography, standard automated perimetry
Visually symptomatic multiple sclerosis (MS) provides only part of the required information to assist in understanding the disease. Recently, researchers have concentrated their efforts on diagnosing MS cases in the subclinical period. The aim of this paper was to assess...
ROPPVAL Syndrome as a differential diagnosis to optic neuritis
1 December 2021
| Claire Howard
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EYE - Neuro-ophthalmology
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Photophobia, ROPPVAL, headache, migraine, optic neuritis, retro-ocular pain
Optic neuritis (ON) is a common cause of visual loss in young patients. Patients with eye pain and ipsilateral visual loss are often referred into neuro-ophthalmology clinics with a possible diagnosis of ON. In 2018 Jefferis et al. reported a...
MRI characteristics of NMO, MOG and MS-related ON
3 June 2021
| Su Young
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EYE - Neuro-ophthalmology
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MRI, Optic nerve, multiple sclerosis (MS), myelin oligodendrocyte glycoprotein antibody disease (MOG-AD), neuromyelitis optica (NMO), optic neuritis
This review article examined differences of MRI appearances that can help clinicians assess and manage these important neuro-ophthalmic disorders. It also examined the role of optic nerve MRI as a prognostic indicator in acute optic neuritis (ON). The major findings...
Investigating MOG-IgG as a cause for optic perineuritis
5 August 2020
| Claire Howard
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EYE - Neuro-ophthalmology
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Optic perineuritis, myelin oligodendrocyte glycoprotein (MOG), aquaporin-4 (AQP4), optic neuritis, optic nerve sheath
Optic perineuritis can be a manifestation of infectious and systemic inflammatory disorders, but in most cases is considered idiopathic. Diagnosis is established by magnetic resonance imaging (MRI) with the demonstration of optic nerve sheath enhancement with sparing of the optic...
Long-term retinal changes following unilateral retrobulbar optic neuritis
1 June 2015
| Claire Howard
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EYE - Neuro-ophthalmology
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OCT, optic neuritis, optical coherence tomography, RNFL, steroid
The aim of this study was to assess the longitudinal changes in retinal nerve fibre layer (RNFL) thickness after a first attack of optic neuritis and to investigate the impact of treatment on RNFL thinning at one year after the...
