You searched for "cyclosporine"

36 results found

Cyclosporine A and pterygium fibroblasts

The matrix metalloproteinases (MMP) are a family of structurally related zinc-dependent extracellular matrix degrading proteinases that have been implicated in facilitating the migration and growth of pterygia. Both MMP- 3 and MMP-13 were found to be overexpressed in the fibroblasts...

Topical cyclosporine A 0.05% for recurrent anterior uveitis

This is a retrospective case-crossover study conducted by reviewing medical charts of patients treated for recurrent anterior uveitis between 2002 and 2011 at the Kellogg Eye Centre by one cornea specialist. The demographics, episodes of anterior uveitis, severity of episodes...

Emerging developments in dry eye

An estimated 344 million people worldwide suffer from dry eye [1]. This chronic syndrome is characterised by a vicious cycle of tear film hyperosmolarity, tear instability and corneal stress, leading to increased friction, inflammation, ocular surface damage and decreased visual...

Birdshot chorioretinopathy: an important differential

Birdshot chorioretinopathy (BSCR) is a relatively uncommon cause of posterior uveitis which often has a relapsing and remitting course [1,2]. We present a case which demonstrates how remission can be obtained for several years using cyclosporine. Case report A 44-year-old...

New Treatments in Noninfectious Uveitis

As a specialist registrar training in Aberdeen there were two important lessons I learned which have proved to be invaluable over the years for two very different reasons. The first lesson learned was to never underestimate the wind chill factor...

Inflammatory macular holes

The authors present a case of closure of a full thickness macular hole in a patient with Behçet’s disease, without surgery. The 23-year-old male they describe presented with a history of recurrent oral aphthous ulcers and a genital ulcer. Ocular...

Cataract surgery in patients with Vogt-Koyanagi-Harada

This retrospective, interventional case series of 286 patients (408 eyes) assessed visual outcome and prognostic factors in patients with Vogt-Koyanagi-Harada (VKH) undergoing cataract surgery between September 2008 and December 2017. Two groups were reviewed. The first group (352 eyes) had...

VKH outcomes with pulse IV steroids

This is a retrospective review of clinical case notes records of 111 Vogt-Koyanagi-Harada (VKH) patients between 1999 and 2015 from a single centre in Tokyo, Japan. The mean age at presentation was 41 years and the median follow-up period was...

PUK after corneal crosslinking

This retrospective study aimed to report the incidence, characteristics, clinical presentations, risk factors, and the available treatment modalities of sterile peripheral ulcerative keratitis (PUK) post-corneal collagen crosslinking (CXL). In total 771 eyes of 474 patients operated for keratoconus or ectasia...

Effective management of dry eye and ocular surface disease

Experts recommend a consistent approach to diagnosis, therapeutic targeting by disease subtype and escalation of therapy when tear substitutes are not sufficient. Experts call for a consistent, unified approach to diagnosis of dry eye disease (DED), with a new simple...

Leber’s hereditary optic neuropathy: from lab to clinic

Leber’s hereditary optic neuropathy (LHON) was the first clinically described mitochondrial disorder (1871). This article reviews the pathophysiology and clinical features of LHON with a focus on translational research. G11778A is currently the most common mutation worldwide and is associated...

Santen makes waves at ESCRS 2019 with significant expansion into surgical devices and publication of real-world evidence in dry eye disease

Santen EMEA’s significant expansion into the surgical devices arena is underlined by the company’s activities at this year’s European Society of Cataract and Refractive Surgeons (ESCRS) congress. In addition to the launch of a new...
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