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A novel way to diagnose optic neuropathies using Bruch’s membrane opening

7 December 2020 | | Neuro-Ophthalmology | Glaucomatous neuropathy, compressive optic neuropathy, minimal rim width, non-arteritic anterior ischaemic optic neuropathy, non-glaucomatous neuropathy
Differential diagnosis of optic neuropathies can be challenging but is crucial for the correct management of the underlying disease and prevention of further damage. Bruch’s membrane opening (BMO) was recently discovered as the anatomical border of the optic disc. BMO...

Acetylcholine receptor antibodies in the diagnosis of ocular myasthenia gravis at the Manchester Royal Eye Hospital

3 August 2023 | | Neuro-Ophthalmology
Myasthenia gravis (MG) is the commonest autoimmune condition to affect the neuromuscular junction. In the UK, its prevalence is 15 per 10,000 [1,2] and recent studies have shown that rates are steadily increasing [3,4]. Aims of this audit The aim...

Investigating the link between corneal clarity and statin use

2 February 2024 | | Cornea / External Eye Disease
Transparency is a vital attribute of the cornea, necessary in preserving healthy vision. Maintaining this requires the collective input of the various layers of the cornea. Mostly, the layers implicated in this are the corneal stroma and endothelium [1]. Our...

The role of inflammation in the pathophysiology of DMO

1 February 2016 | | Retina / Uvea / Vitreous
Diabetic macular oedema (DMO) is a major cause of visual loss in diabetes, with a complex multifactorial pathogenesis. In the UK alone it is estimated that there are nearly 2.5 million diabetic patients aged over 12 years. Approximately 65,000 of...

Pathophysiology of diabetic macular oedema: why combination therapy may be better

1 October 2015 | | Retina / Uvea / Vitreous
The prevalence of diabetes has continued to increase over the years. It is currently estimated that there are 382 million with diabetes worldwide in 2013, and that this figure is expected to rise to 592 million by 2035 [1]. In...