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Retinoblastoma chemotherapeutic drugs and their toxic effects on RPE cells

There is reported clinical evidence of retinal pigment epithelium (RPE) alterations after intra-arterial (IAC) and intravitreal chemotherapy (IViC) of retinoblastoma. The purpose of this study was to investigate the cellular toxic effects of melphalan, topotecan and carboplatin on the RPE...

Adjuvant oral voriconazole or oral ketoconazole for fungal keratitis

This randomised double-blinded trial examined clinical outcomes of 50 patients with severe fungal keratitis treated with either adjuvant oral voriconazole or oral ketoconazole. Inclusion criteria were culture or smear proven fungal ulcers >5mm in maximum diameter, involving >4mm of the...

Intracameral bevacizumab as an adjunct to trabeculectomy

This is a 12-month, prospective, randomised, double-masked, placebo-controlled trial of patients who were not controlled medically with open angle glaucoma and scheduled for a primary trabeculectomy. Patients were recruited and randomised during the period between April 2009 and November 2010....

Hypothyroidsim and acute central serous chorioretinopathy – is there a link?

This cross-sectional study included 71 consecutive acute central serous chorioretinopathy (CSC) patients and 70 age-matched healthy control subjects. Systemic findings, including serum levels of thyroid hormones, thyroid stimulating hormone (TSH), mean arterial pressure (MAP), pulse rate, serum lipid levels and...

Presentation feedback tools

The topic of this issue stems from a desire to find the best free-to-use tool for collecting feedback after a presentation. It is a common requirement for clinicians to collect audience feedback after a teaching session. This feedback contributes toward...

Unconscious bias (part 2)

Does unconscious bias exist, and does training help to reduce discriminatory behaviour? Clare Inkster questions her role as a trainer. I read Gwyn Williams’ Learning Curve article on this topic a few months ago with interest, and as someone who...

See sweet to C-suite: Peter Holland

See also - See sweet to C-suite: Imran Rahman In this three-part conversation series, Co-editor David Lockington speaks with highly influential individuals about their journey to the top, with advice for the next generation of leaders. Part One: David speaks...

The College of Optometrists publishes Interim Position on AI in Eye Care

The College of Optometrists has today published its Interim Position on the Use of Artificial Intelligence (AI) in Eye Care setting out the UK optical sector’s collective stance on the safe and responsible implementation of AI in eyecare. The College...

Human factors in the operating room

The importance of minimising human error in surgery is well established. This was initially sparked by lessons learned from the aviation industry in the 1970s after several fatal flight accidents [1]. This became a catalyst for a movement on training...

Building capacity for diabetic retinopathy services in Malawi

Screening for diabetic retinopathy prevents blindness. There is no systematic screening programme for diabetic eye disease in Malawi and people present when they have lost vision and it is too late for treatment. The aim of the VISION 2020 LINK...

The ocular manifestations of COVID-19: an overview of current literature

Although respiratory symptoms are the most frequent manifestation of COVID-19, multi-organ involvement has been demonstrated, including ocular manifestations. The author investigates how the eye can be affected. The SARS-CoV-2 virus responsible for the COVID-19 pandemic has presented a significant public...

Ophthalmic DOPS and OSATS: The Handbook for Work-Based Assessments

The first thing to say is: “I wish I’d had this book when I was an ST1!” The number of work-based assessments (WBA) required during ophthalmic specialist training (OST) is a daunting prospect to trainee ophthalmologists, particularly ST1s with no...