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Corneal molecular and cellular biology for refractive surgeon
This is an interesting literature review that looks into the recent advances concerning the corneal molecular and cellular processes that are involved in the wound healing response after excimer laser surface ablation and LASIK surgery. It talks about the complex...
LASEK vs. epi-LASIK for myopia: meta-analysis
Previous studies have produced inconsistent conclusions on the relative benefits between LASEK vs. Epi-LASIK. LASEK uses 20% alcohol to separate an epithelial flap from the Bowman membrane. After ablation, the epithelial flap is repositioned onto the cornea. Epi-LASIK creates the...
Effect of preservative free fluoroquinolones on human corneal epithelial cells in vitro
Fluoroquinolones, including second generation (ofloxacin and ciprofloxacin), third generation (levofloxacin and tosufloxacin) and fourth generation (gatifloxacin and moxifloxacin), are a group of bactericidal agents used to treat multiple ocular infections. The third and fourth generation fluoroquinolones have enhanced Gram-positive activity...The role of inflammation in the pathophysiology of DMO
Diabetic macular oedema (DMO) is a major cause of visual loss in diabetes, with a complex multifactorial pathogenesis. In the UK alone it is estimated that there are nearly 2.5 million diabetic patients aged over 12 years. Approximately 65,000 of...
Cornea, 2-Volume Set: Fundamentals, Diagnosis, Management and Surgery of the Cornea and Conjunctiva (4th Edition)
Originally published in 1997 as a comprehensive set of three volumes on cornea and external eye disease, this two volume edition, published at the end of 2016, offers “a complete multimedia resource, in print, online, eBook and video format”. There...
MicroRNAs in cataract
In an ageing population cataract formation is one of the leading causes of blindness. Cataracts are caused by a failure to clear accumulating aggregated proteins in the lens. MicroRNAs are small non-coding transcripts which bind to specific mRNAs acting at...
Limbal melanocytes and the stem cell niche
The cornea is continually regenerated to maintain clear vision, due to a population of stem cells located in the limbal region between the cornea and the conjunctiva. These limbal stem cells (LESC) reside in crypts in structures called the Pallisades...
Autophagy in lens mitochondria loss
The lens consists of a monolayer of epithelial cells that overlies fibre cells that differentiate from epithelial cells at the equator. While developing, fibre cells need mitochondria to provide energy, as they mature they lose these and other organelles to...Moorfields: Cataract, medical retina and disc assessment
The Cataract/medical retina/ disc assessment short course has been designed to meet the training needs of band 6’s and 7s who wish to develop their knowledge and skills in disease recognition, management and intervention of cataract, medical retina and disc...
Glaucoma and erectile dysfunction
In this cross-sectional study with patient questionnaire and retrospective chart review, a total of 167 male patients over 40 years of age were enrolled. Exclusion criteria included previous exposure to radiation and surgical treatment for prostate benign hypertrophy or malignancy....
Transfected RPE cells inhibit AMD in rats
Age-related macular degeneration (AMD) is a leading cause of blindness in the elderly. Wet AMD is characterised by choroidal neovascularisation, new vessels into the retina, leading to leakage and tissue damage. Many proangiogenic factors particularly vascular endothelial growth factor (VEGF)...
