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Development of testing protocols for high and low contrast visual acuity
Dysfunction of the afferent visual system, characterised by impairments in high-contrast visual acuity (HCVA) and low-contrast visual acuity (LCVA) have been demonstrated in some neurological conditions such as multiple sclerosis and Parkinson’s disease. HCVA and LCVA are also potential quantitative...
Subfoveal choroidal thickness and PCV
This report studies the prognostic factors for visual improvement and the need for additional treatments at one year after the initial combination therapy of intravitreal ranibizumab injection or intravitreal aflibercept injection followed by PDT in eyes with PCV. Fifty-six eyes...
Retinal blood flow changes in glaucoma
This study examined the changes in retinal blood flow and vessel diameter after IOP reduction in high- and low-pressure glaucoma; exfoliation glaucoma (ExG) and normal-tension glaucoma (NTG). Glaucoma progression is seen at times in eyes despite IOP reduction and changes...
Effect of rebubbling after DMEK
This study objectively evaluated the impact of rebubbling on postoperative corneal clarity and endothelial cell loss (ELD) after DMEK. This was a retrospective analysis of 132 consecutive DMEK cases performed for Fuchs endothelial dystrophy or pseudophakic bullous keratopathy. Patients were...
Using frequency doubling technology perimetry to identify Alzheimer’s disease early
Alzheimer’s disease is widely reported to be associated with deficits in visual function. Visual disturbances include impaired stereopsis, contrast sensitivity and motion detection. Deficits specific to the magnocellular pathway (MGC) have been identified in Alzheimer’s disease. This article compares the...
Macular thickness and visual fields
The authors describe a comparison of spectral domain OCT with Humphrey visual fields (HVF) mean deviation (MD) and pattern standard deviation (PSD), examining the retinal thickness of the macula and circumpapillary retinal nerve fibre layer (RNFL) defects. Seventy-three subjects who...
Does Ozurdex affect perfusion status in vein occlusion?
Ozurdex (intravitreal dexamethasone implant) has been approved by National Institute of Health & Care Excellence (NICE) for treatment of patients with macular oedema associated with vein occlusion. This study looks at the change in peripheral perfusion status in patients with...
PRN Ranibizumab verses continuous aflibercept in UK clinical practice
This was a multicentre (21 UK hospitals), national EMR study on treatment naïve nAMD eyes, undergoing predominantly as needed (PRN) Ranibizumab or continuous (fixed or treat and extend - (F/TE)) Aflibercept (Af). The primary outcome was change in vision at...
Moxifloxacin 0.5% for bacterial keratitis
The authors report on the results of a randomised controlled trial comparing commercially available non-preserved moxifloxacin 0.5% vs. a combination of fortified cefazolin 5% and tobramycin 1.3% in the treatment of moderate bacterial keratitis without perforation. Corneal scrapings were collected...
Cytokine levels in vitreous fluid in patients with pathological myopia
Pathological myopia (PM) is a leading cause of irreversible visual impairment worldwide, and efforts are dedicated to the study of its underlying mechanisms. Axial extension of the eyeball is regulated via a cascade of biochemical molecules that are initiated in...
Relating metamorphopsia severity and OCT findings in advanced epiretinal membranes
The authors present the findings of a retrospective study to correlate metamorphopsia and ectopic inner foveal layers (EIFL) or ‘central bouquet’ abnormality (CBA) in patients with advanced stages of epiretinal membrane (ERM) following the new OCT‐based grading scheme as described...
