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The paediatric cataract: an overview of the embryology and pathophysiology

5 February 2020 | | EYE - Paediatrics, EYE - Strabismus, EYE - Cataract, EYE - Refractive, EYE - General
In the first of the two articles (see Part 2 here) on paediatric cataracts, Samuel Aryee reviews the aetiology of this condition. Cataracts arise from opacification of the natural transparent lens, which can cause partial or total blindness. Although the...

Regulatory drug evaluations and expedited review initiatives: EU and US perspectives

1 April 2016 | | EYE - General
The European Medicines Agency (EMA) and United States Food and Drug Administration (FDA) each conduct independent assessments of benefit-risk profile when evaluating applications to market new or modified medicines, and their respective decision-making is guided by distinct legislation, procedures and...

“My cataracts have been dissolved by eye drops!”

1 April 2018 | EYE - Cataract, EYE - Refractive
Simerdip Kaur takes a look at the latest ophthalmology-related news stories and asks which are scientific reality and which are ‘fake news’. Headline: “My cataracts have been dissolved by eye drops!” I’m sure some of us have had patients enquire...

Macula re-attachment following intravitreal ranibizumab in rhegmatogenous retinal detachment

1 February 2015 | | EYE - Vitreo-Retinal, EYE - General
Ranibizumab (Lucentis) is a vascular endothelial growth factor inhibitor (anti-VEGF) used for treatment of choroidal neovascular membrane [1]. We report a case where macula off inferior rhegmatogenous retinal detachment was misdiagnosed as wet age-related macular degeneration (AMD) and three intravitreal...

Shedding light on Wolfram syndrome: The unveiling of a delayed diagnosis

12 August 2025 | | EYE - Neuro-ophthalmology
Wolfram syndrome 1 (WS1) was first described by Wolfram and Wagener in 1938 and it’s a rare neurodegenerative, progressive disorder, also known as DIDMOAD (diabetes insipidus, diabetes mellitus, optic atrophy, and deafness) [1]. We present an atypical case of WS...

A window to 2024 and beyond?

3 April 2024 | | EYE - Cornea
The connection between the eye and systemic diseases has been acknowledged for millenia. Historical records suggest that ancient civilisations had some understanding of the eye’s significance beyond its primary function in vision. For instance, in ancient Egypt, the ‘Eye of...

A closer look at the new wave of glaucoma surgery – radical or old school?

1 October 2016 | | EYE - Glaucoma
Glaucoma is a challenging condition to treat because the exact pathophysiology remains unclear and the only readily modifiable factor is the intraocular pressure (IOP). Additionally, most glaucoma patients are completely asymptomatic, yet are often subjected to lifelong medical therapy. The...

Management of diabetic macular oedema in vitrectomised eyes

1 August 2016 | | EYE - Vitreo-Retinal
Diabetic macular oedema (DMO) is one of the leading causes of blindness; its prevalence is on the rise with progressive increase in numbers of people suffering from diabetes. The management of DMO has evolved significantly over the past few years....

Improved efficacy expected with second-generation microinvasive glaucoma surgery (MIGS) devices

1 July 2015 | | EYE - Glaucoma
Microinvasive surgical approaches to primary open-angle glaucoma (POAG) offer minimally traumatic options for effective intraocular pressure (IOP) reduction in appropriately selected glaucoma patients. Increases in laser trabeculoplasty rates and wider adoption of glaucoma drainage device filtration procedures, together with the...

Clinical and management strategies in glaucoma practice: perspectives from international glaucoma specialists

1 April 2015 | | EYE - Glaucoma
Management options and outcomes in glaucoma practice were reviewed at the 7th Moorfields International Glaucoma Symposium, held in London on 24 January 2015. This article summarises perspectives from international glaucoma specialists on debated issues in topical therapy, glaucoma surgery, diagnostic...

The interpretation and use of ultrasound biomicroscopy (part 1)

1 October 2016 | | EYE - Cornea, EYE - Imaging, EYE - Vitreo-Retinal
Ultrasound Biomicroscopy (UBM) has become increasingly important for the diagnosis of a variety of anterior segment pathologies. Most ophthalmologists are familiar with conventional B-scan ultrasonography techniques, which operate at lower sound frequencies (7.5 to 20MHz). UBM is an ultrasound technique...

Glaucoma-NET: a novel way of improving glaucoma management in sub-Saharan Africa

1 June 2022 | | EYE - Cornea, EYE - General
Background Glaucoma is the second most common cause of blindness worldwide [1]. People with untreated glaucoma suffer from irreversible, progressive loss of sight. The disease is characterised by progressive loss of visual field, with pathological cupping of the optic disc...