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Aflibercept, bevacizumab or ranibizumab for DMO

1 August 2016 | | EYE - Vitreo-Retinal
This is a two-year randomised clinical trial of 660 patients with visual acuity impairment from diabetic macular oedema (DMO) who were randomised to monthly injections of 2.0mg aflibercept, 1.25 mg bevacizumab or 0.3mg ranibizumab. Focal or grid laser was performed...

Using OCT to screen and monitor Alzheimer’s disease

1 June 2016 | | EYE - Neuro-ophthalmology | Macular thickness, mild cognitive impairment, optical coherence tomography, subjective memory complaints
Alzheimer’s disease (AD) is a neurodegenerative illness characterised by progressive decline in cognitive function. AD is the main cause of dementia worldwide. Over recent years researchers have strived to find biomarkers to diagnose AD, particularly in the early stages of...

AMD and visceral fat and pro-inflammatory factors

1 December 2015 | | EYE - Vitreo-Retinal
Several large studies have shown a positive relationship between age-related macular degeneration (ARMD) and high body mass index. The waist-hip ratio is also associated with development of early AMD. Visceral fat has a pro-inflammatory effect, which means it has an...

OCT use with macular retinoblastoma

1 April 2015 | | EYE - Paediatrics, EYE - Strabismus
The authors explore the use of portable hand-held spectral domain OCT (SD-OCT) in three eyes of three infants and young children with macular retinoblastoma. All were treated with chemotherapy and all had SD-OCT before and after treatment. The children were...

Ranibizumab for the treatment of age-related macular degeneration

1 April 2015 | | EYE - Vitreo-Retinal
This multicentre randomised prospective open label study compared 0.5 versus 2mg of ranibizumab in patients with submacular retinal pigment epithelial (RPE) detachment due to age-related macular degeneration. Four treatment regimens were used for the two strengths either monthly for 12...

Role of fundus autofluorescence patterns and baseline atrophy area on geographic atrophy progression

1 December 2014 | | EYE - Vitreo-Retinal
Central geographic atrophy (GA) is one of the morphological sub types of late-stage macular degeneration. The natural course of the disease is characterised by expanding areas of macular atrophy, which cause absolute scotoma. Fundus autofluorescence (FAF) is derived from lipofuscin...

Correlation between anti-retinal antibodies and proliferative vitreoretinopathy (PVR)

1 October 2018 | | EYE - Vitreo-Retinal
The pathological basis of PVR is not clearly understood and there are no effective medications targeting this condition. This cross-sectional study looked at the possible association of anti-retinal antibodies with patients with PVR and retinal detachment (RD). Aqueous and vitreous...

Do bilateral same day intravitreal injections increase the risk of endophthalmitis?

1 February 2019 | | EYE - Vitreo-Retinal
This large retrospective cohort study reviewed all patients who had bilateral intravitreal anti-vascular endothelial growth factor (VEGF) injections between April 2012 and August 2017. There were 101,932 procedures performed in 5890 patients. The two most common indications for injections were...

Acetazolamide and CMO

1 August 2019 | | EYE - Vitreo-Retinal
The authors set out to analyse the effect of acetazolamide therapy on inflammatory cystoid macular oedema (CMO) as defined by change in central macular subfield thickness (CST), as well as its effect on visual acuity. A retrospective chart review was...

The approach to trabeculectomy postoperative complications

1 August 2016 | | EYE - Glaucoma
Performing a trabeculectomy is like giving birth to a baby. It may be traumatic and there is scope for devastating error but once the operation is completed only then does the real work begin. The bleb must be nurtured into...

Ophthalmic mentors: Professor Sir Peng Tee Khaw

1 December 2014 | | EYE - Cataract, EYE - Cornea, EYE - Glaucoma, EYE - Imaging, EYE - Neuro-ophthalmology, EYE - Oculoplastic, EYE - Oncology, EYE - Orbit, EYE - Paediatrics, EYE - Pathology, EYE - Refractive, EYE - Strabismus, EYE - Vitreo-Retinal, EYE - General
In the second of our interviews in this series, Eye News speaks to Professor Sir Peng Tee Khaw, Professor of Glaucoma and Ocular Healing, Consultant Ophthalmic Surgeon, Director of the National Institute for Health Research, Biomedical Research Centre at Moorfields...

Exploiting nature’s randomised trials of eye disease

1 December 2022 | | EYE - Glaucoma, EYE - Vitreo-Retinal, EYE - Orbit
Confounding and reverse causation in observational ophthalmic epidemiology Traditional observational studies are inherently limited in establishing a causal effect of an exposure on an outcome of interest. One fundamental limitation is confounding, whereby causation is incorrectly attributed to a third...