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A mouse model for uveal melanoma
Uveal melanoma (UM) is the most common malignant tumour arising within the eye and is a severe threat for both sight and life, due to a high risk of metastasis. There are no animal models of UM, but the Tg(Grm1)...The impact of obstructive sleep apnoea monitoring functionality on smartwatches: a new frontier for ophthalmologists
Dawn of a new era in wearable technology? Smartwatches have really stepped up their game and have evolved from telling time to keeping an eye on our health. In February 2024, the United States Food and Drug Administration (FDA) gave...New AOP members elected to join Hospital Optometrists Committee
The appointment of Lucy Andrews and Claire Melvin confirmed at the AOP’s Hospital and Specialty Optometrists Conference.A case of ‘60-day glaucoma’
Neovascular glaucoma (NVG) has been called ‘90-’ or ‘100-day glaucoma’ in the past due to its typical development three months after the onset of central retinal vein occlusion (CRVO). In reality, NVG can occur anywhere between two weeks and two...Informed consent in ophthalmology care in the UK: A critical component of patient‑centred practice
Informed consent is a cornerstone of ethical and legal practice in healthcare, particularly in fields like ophthalmology where specialised interventions can have significant implications for a patient’s vision and quality of life. In the UK, informed consent is not merely...
Importing iron to the retina
In the retina, iron is particularly critical for the visual phototransduction cascade. In the retinal pigment epithelium (RPE), RPE65 activity leads to 11-cis-retinaldehyde, the photosensitive component of rhodopsin production and iron containing enzymes are necessary for disc replacement in photoreceptor...
Sustained elevation of extracellular ATP in chronic glaucoma
Although adenosine 5′-triphosphate (ATP) release from retinal neurons and astrocytes has been demonstrated in short-term increases in intraocular pressure (IOP); such as in aqueous humor of humans with primary acute angle closure glaucoma, the response in chronic IOP elevation was...
Brn3b neuroprotective effect in rat glaucoma model
An adeno-associated virus-directed overexpression of the Brn3b protein in hypothesised to confer neuroprotective effects in this paper. This is ultimately tested in a well-accepted rat glaucoma model (Morrison’s model: saline injection into episcleral veins of rat eyes with a force...
BT for convergence spasm
The aim of this study was to analyse the response of a cohort of patients with convergence spasm to the injection of botulinum toxin (BT) in the medial rectus muscle. This was a retrospective study of six patients with a...
Adjustment under topical anaesthesia in children
This is a study of 19 cases of strabismus surgery using topical aesthetic and intraoperative adjustment in selected children. The study included 14 males and five females with mean age of 12.68 ±2.5 years (range 8-16). Five were esotropia and...
BT as a diagnostic tool in Duane’s retraction syndrome
This study evaluated the effects of botulinum-toxin (BT) on management of Duane’s retraction syndrome along with how BT can be used diagnostically to help with patient expectations and decide management. Functional and psychosocial impact of BT effect was evaluated in...
