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Management of a giant pigment epithelium detachment with transition from half- to full-dose aflibercept
This case report describes the management of a giant pigment epithelial detachment (PED) in neovascular age-related macular degeneration (nAMD) using half-dose aflibercept. An 80-year-old woman presented with a huge PED (maximum height 1338µm) and multiple risk factors for retinal pigment...Possible COVID-19 related maculopathy
COVID-19 is being investigated as a potential cause for various ocular diseases, with growing evidence of related retinal vascular changes, that vary from isolated cotton wool spots and retinal haemorrhages to retinal vascular occlusions [1.2]. COVID-related macular affection has also...Ultrasound biomicroscopy (part 2): primary angle closure
Patients with primary angle closure or primary angle closure glaucoma [PAC(G)] comprise a significant subgroup affecting around 10% of glaucoma patients amongst Caucasians. Assessment of the patient with angle closure, or narrow angles, requires gonioscopy. However, whilst identifying the presence...
Air toxicity on retinal pigment epithelium
This study investigated the potential toxic effects of air on primary human retinal pigment epithelial (RPE) cells in vitro. Clinically during pars plana vitrectomy air is used as either a temporary tamponade during air-fluid exchange or mixed with gas to...
Precision and accuracy of TearLab osmometer
Measuring tear osmolarity has been identified as a potential method for objectively diagnosing dry eye. TearLab osmolarity system is an in situ osmometer which may be a promising candidate for clinical use as it is portable and only requires a...
LASEK vs. epi-LASIK for myopia: meta-analysis
Previous studies have produced inconsistent conclusions on the relative benefits between LASEK vs. Epi-LASIK. LASEK uses 20% alcohol to separate an epithelial flap from the Bowman membrane. After ablation, the epithelial flap is repositioned onto the cornea. Epi-LASIK creates the...
Does mitomycin C improve success rates in DCR surgery?
The authors present a meta-analysis of the use of mitomycin C (MMC) as an adjunct in dacrocystorhinostomy (DCR) surgery. Fifteen randomised control trials were included. There was a degree of heterogeneity in the surgical technique used, however, the MMC is...
The effect of everolimus on retinal pigment epithelium and proliferative vitreo-retinopathy
The principal cells involved in proliferative vitreo-retinopathy (PVR) are retinal pigment epithelial cells (RPE). Everolimus is a drug used in renal cell carcinoma which targets and inhibits a key regulatory protein in cancer (mTOR). In this study, the authors investigated...
A relationship between central serous retinopathy and obstructive sleep apnoea
This prospective study aimed to evaluate a relationship between central serous retinopathy (CSR) and obstructive sleep apnoea (OSA). Twenty-three subjects (six female and 17 male) were diagnosed with CSR and overnight polysonography was performed to record desaturation and apnoeic episodes....
Review of bupivacaine use in treatment of strabismus
This review aimed to assess the applications of bupivacaine (B) in the non-surgical treatment of strabismus in human and animal studies. Animal studies show that singly-innervated fibres with low concentrations of mitochondria and developed sarcoplasmic reticulum are more affected by...
Surgical correction of lacrimal gland prolapse
This is a systematic review of published literature on the management of lacrimal gland prolapse or ptosis. The authors found 16 publications which contained a description of any surgical correction of a prolapsed lacrimal gland, comprising seven case reports, four...
