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Leber’s hereditary optic neuropathy: from lab to clinic

Leber’s hereditary optic neuropathy (LHON) was the first clinically described mitochondrial disorder (1871). This article reviews the pathophysiology and clinical features of LHON with a focus on translational research. G11778A is currently the most common mutation worldwide and is associated...

RaScaL Study

The RaScaL study was a six month, single-centre, controlled, prospective phase I/II study in which subjects with diabetic macular oedema (DME) and associated peripheral nonperfusion on ultrawide-field fluorescein angiography (UWFA) were randomised to: (1) study arm: ranibizumab (0.5 mg) injection...

Clinical Applications of Optical Coherence Tomography Angiography

Clinical Applications of Optical Coherence Tomography Angiography provides an informative, up-to-date review of the numerous applications of OCTA in ophthalmology. This book highlights the ways in which this relatively recent non-invasive imaging technique has been an invaluable tool for our...

Obituary: Sohan Singh Hayreh (1927 - 2022)

Sohan would have been 95 on 6 November this year, but due to complications of COVID-19, he passed away on 29 September.

A brief history of colour vision

Andrew Want takes a look at how colour vision has evolved in humans and animals and how it differs across species. Colour vision is something that we often take for granted, but it has become so intrinsic to the way...

Short-term effects of intravitreal bevacizumab on the cornea

Bevacizumab has been extensively used to treat macula oedema and neovascularisation of the retina and it has also been useful in the management of corneal neovascular diseases. This prospective study aimed to provide more information on the effect bevacizumab may...

Avoiding pre-placed recti sutures in enucleation

This is a retrospective review of 40 patients who underwent enucleation using a non-conventional technique in which the recti muscles were detached from the sclera without pre-placing any sutures to secure the cut muscle ends. The surgery was only performed...

Proning and the pandemic - ocular complications seen in critical care

Priyanka Sanghi and her co-authors explore the ocular complications seen in critical care units throughout the country as we treat patients through this challenging time. The SARS-Cov-2 (COVID-19) pandemic has placed the NHS and critical care services under immense strain,...

Preview: Oxford Ophthalmological Congress

Between 1–3 July, we will be heading down to England for the 107th Oxford Ophthalmological Congress.

The Lily Foundation celebrates approval of first ever mitochondrial disease treatment by NICE

The Lily Foundation, the UK’s leading mitochondrial disease charity, is today celebrating a landmark achievement in the fight against the disease – the first ever treatment for a mitochondrial condition has been approved for use on the NHS in England....

East of Ealing

“And Cain said unto the Lord, my punishment is greater than I can bear. Behold, thou hast driven me out this day from the face of the earth; and from thy face shall I be hid. And Cain went out...

Combined ranibizumab and ablative therapy for Coat’s disease

The aim of this study was to observe the efficacy of intravitreal ranibizumab (IVR) combined with laser photocoagulation or cryotherapy, for Coats’ disease. Patients younger than 16 years of age who were diagnosed with Coats’ disease were included in this...