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This prospective case-control study aimed to assess the potential of optical coherence tomography (OCT) and OCT angiography (OCTA) in distinguishing between glaucoma and pituitary macroadenoma based on optic disc appearance. Thirty-one patients (23 with glaucoma, eight with pituitary macroadenoma) were included. Glaucoma patients exhibited significantly lower peripapillary retinal nerve fibre layer thickness (65.79 ±15.46, 86.0 ±11.37, respectively, p=0.002) and rim area (1.00 ±0.22mm2 and 1.2 ±0.15mm2, respectively, p=0.005). On OCTA, peripapillary vessel density was significantly lower in all quadrants in the glaucoma group. These differences persisted even when stratified by visual field mean deviation. The authors conclude that these parameters from combined OCT and OCTA may be useful for the initial differentiation of these optic neuropathies.

Optical coherence tomography angiography for the differentiation of glaucoma from pituitary macroadenoma related optic disc measurements.
Zahavi A, Weinberger Y, Geffen N, et al.
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Su Young

Moorfields Eye Hospital NHS Trust, London, UK.

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