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Leber’s hereditary optic neuropathy: from lab to clinic

Leber’s hereditary optic neuropathy (LHON) was the first clinically described mitochondrial disorder (1871). This article reviews the pathophysiology and clinical features of LHON with a focus on translational research. G11778A is currently the most common mutation worldwide and is associated...

Detecting apoptosis in retinal cells

This is a review paper in which the authors summarise the transitioning of techniques detecting apoptosis from bench to bedside, along with the future possibilities they encase. Detection of Apoptosis in Retinal Cells (DARC) technology can be used as a...

Pseudophakic Monovision: A Clinical Guide

The contents of this small volume should provide useful tips for all ophthalmic practitioners involved with managing patients undergoing cataract surgery. For those ophthalmic clinicians and supporting staff not familiar with the potential options for achieving a spectacle independent refractive...

Trabeculectomy for normal tension glaucoma

This is a retrospective consecutive, non-comparative case series of 131 eyes of 98 patients undergoing trabeculectomy between 2007 and 2013 in a normal tension glaucoma (NTG) clinic. Assessment of the clinical outcomes include intraocular pressures (IOP) reduction, bleb formation, final...

Scleral fixation using Gore-Tex suture of a subluxated PCIOL

This was a retrospective single-centre study of patients who underwent lasso in-the-bag scleral fixation of a subluxated posterior chamber (PC) intraocular lens (IOL) using the snare technique with Gore-Tex suture from 2019 to 2021. Functional outcome was analysed by clinical...

Single muscle surgery for hypertropia

The authors undertook partial tenotomies combined with graded marginal recession of single vertical rectus muscles to treat small angle hypertropia in four adults with fusion potential. They report dose response, surgical technique and outcomes. Dose response closely matched the theoretical...

Stimulus type vs. convergence measures

The aim of this study was to investigate if near point of convergence (NPC) would improve when a fixation target with centrally placed 3-D features (to increase binocular disparity stimulus) was used in comparison to a target using only centrally...

Occlusion amblyopia

The authors report a case of binocular diplopia developing in an eight-year-old autistic child following two hours of total occlusion per day for six weeks. The child did not automatically resuppress once occlusion was stopped. Occlusion with Blenderm tape prevented...

Amblyopia treatment review

This review paper summarises the main causes and neural mechanisms that characterise amblyopia. The authors analysed neuroanatomical, neurophysiological and electrophysiological studies in the literature to better understand actual treatment regimens and evaluate new therapeutic possibilities. They considered causes of strabismus,...

Cluster of cyclic esotropia cases

This study reports a series of five patients with cyclic esotropia presenting within a period of 19 months in 2015-16 in one institute. Brain MRI scans were abnormal in two patients (twins) with abnormal white matter signal in the frontal...