This study reports a series of five patients with cyclic esotropia presenting within a period of 19 months in 2015-16 in one institute. Brain MRI scans were abnormal in two patients (twins) with abnormal white matter signal in the frontal lobe. Three cases complained of diplopia, irritability or distress when esotropic. Four had a family history of strabismus. All had a 48-hour cycle. Surgery for all cases was conducted and all regained full binocular vision with one needing a second procedure for recurrent esotropia. No explanation was found for the surge of five cases within the short time period.