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PD-1 and PD-L1 in exenteration specimens

This is an immunohistochemical study looking at variation in the expression of the programmed death-1 receptor (PD-1) and the programmed cell death ligand-1 (PD-L1), comparing cutaneous malignancies which invaded the orbit with uncomplicated nodular basal cell carcinomas. The authors retrospectively...

Correlation between structural and functional status of optic nerve and retina in multiple sclerosis

Multiple sclerosis (MS) involves autoimmune inflammatory demyelination and axonal degeneration in the central nervous system. Investigation of the retina and optic nerve head (ONH) is an ideal way to visualise this demyelination. This study investigates the functional and structural properties...

Angle of deviation and psychological impact

This questionnaire-based prospective study using the Psychological Impact Questionnaire was designed to investigate whether the size of the angle of deviation, age, sex, presence of diplopia, visual acuity of the worse eye and direction of deviation are related to psychological...

Topical doxycycline for corneal neovascularisation

Six eyes with corneal vascularisation were treated with 1% topical doxycycline, four times a day for three weeks. The patients were reviewed at various intervals over a period of one year. The eyes selected had neovascularisation secondary to a variety...

High-fluence collagen cross-linking

The authors treat seven eyes with progressive keratoconus with a high energy (18mW) for five minutes delivering a total energy similar to that suggested by the original Dresden protocol (3mW for 30mins). All eyes had a thickness >400µm following epithelial...

Case reports of neuro-ophthalmological complications of CIPD

The authors present three cases of neuro-ophthalmological complications of chronic inflammatory demyelinating polyradiculoneuropathy (CIPD). CIPD can lead to prominent nerve hypertrophy which can mimic other forms of neuropathy radiologically. In addition, complications can occur which can cause diagnostic difficulties. All...

Aberrant regeneration rates following traumatic oculomotor palsy

Traumatic oculomotor nerve palsies can result in aberrant regeneration / synkinesis which impairs normal facial function. In this paper, the authors retrospectively reviewed the records of 16 patients with traumatic oculomotor nerve palsies who were treated with or without steroids....

Using a pupillometer to confirm presence of RAPD in post stroke homonymous hemianopia

It has been reported that relative afferent pupillary defects (RAPDs) may be present in patients with occipital lobe lesions. However, a small contralateral RAPD due to a difference in the crossed and uncrossed fibres can be difficult to detect using...

Use of the RAPDx device to evaluate efficacy of treatment in patients with optic nerve disease

The RAPDx objectively determines the RAPD magnitude by alternately presenting light stimuli to each eye and deriving amplitude and latency scores. The authors of this paper evaluated the amplitude and latency scores from the RAPDx together with other ophthalmic investigations...

Strabismus measurement comparisons

The authors conducted a prospective study to compare the measurements obtained by objective alternate prism and cover test (PCT) and the subjective red glass test in 72 patients aged 60 years on average and with a mean visual acuity of...

Progression of high anisometropia in children

This study aimed to analyse the stability and progression of higher degrees of myopic anisometropic in children. This retrospective study included 63 children meeting the inclusion criteria. Mean age at initial visit was 4.3 years ±2. There were 51% males...

Comparison of methods of central corneal thickness measurement in glaucoma

This prospective study was done to compare the accuracy and reproducibility of central corneal thickness measured by hand-held and disc-mounted ultrasound pachymeter in glaucoma patients. Sixty-five patients were included in the study. Patients with corneal diseases, corneal astigmatism >3 diopters...