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Importing iron to the retina

In the retina, iron is particularly critical for the visual phototransduction cascade. In the retinal pigment epithelium (RPE), RPE65 activity leads to 11-cis-retinaldehyde, the photosensitive component of rhodopsin production and iron containing enzymes are necessary for disc replacement in photoreceptor...

Complement Factor H and Factor H-Like protein are expressed in human RPE cells

The role of inflammation in age-related macular degeneration (AMD) is well documented and the association of AMD with the inflammatory marker C-reactive protein (CRP) and members of the complement system underline the role of complements in AMD. Human complement factor...

Progression of high anisometropia in children

This study aimed to analyse the stability and progression of higher degrees of myopic anisometropic in children. This retrospective study included 63 children meeting the inclusion criteria. Mean age at initial visit was 4.3 years ±2. There were 51% males...

Review of extraocular muscle biopsies and utility of biopsy in extraocular muscle enlargement

This is a retrospective case series study from Melbourne, Australia, of 93 patients with extraocular muscle (EOM) enlargement who underwent an EOM biopsy between March 1992 and January 2017. Statistical analysis was performed to compare the data between patients with...

Graded Andersons procedure for nystagmus

The authors performed a recession of yoked muscles in patients with idiopathic infantile nystagmus (IIN) in a graded manner based on the amount of head turn. This was a retrospective case series of 37 patients; 26 males, 11 females aged...

Progression of macular atrophy in Stargardt disease

The authors present a study of a cohort of patients with genetically proven ABCA4 gene mutation related Stargardt disease. They aimed to quantify the effect of lesion location and topography on disease progression using fundus autofluorescence imaging. One hundred and...

Embracing assistive technology in the fight against sight loss

The author shares his own experience of sight loss and explains the vital role assistive technology can play in the lives of visually impaired patients. There is no doubt that sight loss continues to be a clear and present danger,...

The work of BIPOSA

The British and Irish Paediatric Ophthalmology and Strabismus Association (BIPOSA) was set up in 2008 to merge two streams of ophthalmology, namely the practice of paediatric ophthalmology and the practice of strabismus (to include refracting in children, and strabismus in...

Glaucoma UK announces winners of the 2025 ‘Excellence in Glaucoma Care Award’

Glaucoma UK is delighted to announce the winners of this year's Excellence in Glaucoma Care Awards – Patrick (Paddy) Gunn from Manchester and Alex Gage Family Optometrists in Sheffield. This annual award celebrates individuals or teams who have made remarkable...

Exciting opportunities for ophthalmic surgeons with the UK and Europe’s leading private provider of cataract surgery, lens replacement surgery and laser eye surgery

At Optical Express we are focused on delivering exceptional patient care, outstanding clinical outcomes and continued investment in our people and technology. For over 30 years, millions of patients have trusted Optical Express with their eye care.

Commonest mistakes during the refraction certificate exam

Ophthalmology specialty trainees are required to pass the refraction certificate exam within the first two years of training. If one passes this exam before entering a training programme, this can add two points to the portfolio during applications. In this...

A tale of two membranes

It was the best of times, it was the worst of times... It was the season of Light, it was the season of Darkness... I am fortunate to work on a vitreoretinal firm at the moment and only a few...