You searched for "metastatic"
Choroidal folds
Choroidal folds are undulations of the choroid, Bruch’s membrane and pigment epithelium, with wrinkling of the overlying retina. They may be idiopathic but can also be caused by a number of different conditions. Case report A 60-year-old male patient was...
Squamous metaplasia of conjunctival epithelial cells with soft contact lens wear versus non-lens wearers
Conjunctiva is composed of non-squamous epithelial cells interspersed with goblet cells, which is a secretory epithelium. Squamous metaplasia is a transformation to non-secretory epithelium, ‘keratinised’ and enlargement of the conjunctival non-goblet cells and relatively shrunken nuclei are seen on impression...
PERG as a visual prognosticator in chiasmatic tumours
Pattern electroretinogram (PERG) allows assessment of ganglion cell function and may therefore be used to assess anterior visual pathway dysfunction. This prospective non-randomised study assessed PERG before and after surgical removal of tumours in and around the sellar region compressing...
Orbital rhabdomyosarcoma treatment characteristics
The aim of this study was to review the clinical presentation, management, local and systemic outcomes of 14 orbital rhabdomyosarcoma (OR) cases with the focus on the role of surgery as treatment. The mean age at presentation was eight years...
A mouse model for uveal melanoma
Uveal melanoma (UM) is the most common malignant tumour arising within the eye and is a severe threat for both sight and life, due to a high risk of metastasis. There are no animal models of UM, but the Tg(Grm1)...
MicroRNA mediate retinoblastoma signal transduction
MicroRNAs (miR) are small non-coding single-stranded RNA molecules, normally 22 nucleotides long. There is a large family of miR that control protein expression by binding to mRNAs, leading to their degradation. One important role of miR is in tumours where...
A prospective trial of adjuvant therapy for high-risk melanoma
Patients diagnosed with iris, ciliary body or choroidal melanoma of high-risk tumour cytogenetics (monosomy 3>/= 20% of cells), were treated with adjuvant low-dose dacarbacine (DTIC) and interferon –alpha-2b (IFNA-2b), following primary treatment (enucleation, brachytherapy or resection). DTIC was given intravenously...
CD73 in aggressive basal cell carcinoma
This is a retrospective review looking at levels of CD73 in aggressive basal cell carcinomas (BCCs) that invade the orbit. Eleven patients who underwent orbital exenteration for invasion by BCCs were compared with 10 matched controls who had simple nodular...
Carcinoid tumours
This is a retrospective review of 28 patients with carcinoid tumours affecting the orbit. The mean age at presentation of the orbital involvement was 62 years, with a slight female preponderance, and 21% had carcinoid syndrome. Proptosis and diplopia were...
