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Pathophysiology of diabetic macular oedema: why combination therapy may be better

The prevalence of diabetes has continued to increase over the years. It is currently estimated that there are 382 million with diabetes worldwide in 2013, and that this figure is expected to rise to 592 million by 2035 [1]. In...

Ophthalmology in the Middle East: Reflections from two electives in Jordan and the UAE

In the summer of 2021, I was fortunate enough to embark on two electives in ophthalmology at the Shami Eye Centre in Amman, Jordan, and Moorfields Eye Hospital in Dubai, United Arab Emirates (UAE). These eye hospitals serve distinct populations,...

Eyes on Tomorrow podcast: “Desert Island Discs for ophthalmologists”

What happens when an ophthalmologist and optometrist get chatting in a pub, over a couple of pints of Guinness, about how they could create something educational and entertaining for ophthalmologists and optometrists? The answer is the Eyes on Tomorrow podcast....

Using graphical illustration to predict giant cell arteritis

A nomogram is a chart or graph of scaled variables that facilitates the approximate computation of a mathematical function via intersecting lines. The objective of this study was to illustrate the use of a nomogram for the prediction of giant...

Ocular surface special: Ocular manifestations of Stevens-Johnson syndrome

Stevens–Johnson syndrome (SJS) is an uncommon dermatological emergency on the same clinical spectrum as toxic epidermal necrolysis (TEN). SJS is characterised by an acute, immune-mediated attack on the skin and mucous membranes, producing a rapidly progressive erythematous eruption with blistering...

The role of inflammation in the pathophysiology of DMO

Diabetic macular oedema (DMO) is a major cause of visual loss in diabetes, with a complex multifactorial pathogenesis. In the UK alone it is estimated that there are nearly 2.5 million diabetic patients aged over 12 years. Approximately 65,000 of...

Treatment of diabetic macular oedema

Diabetic macular oedema (DMO) is a common complication associated with diabetic retinopathy, and the most common cause of visual impairment in diabetes [1]. With predicted rising levels of diabetes (in England by 2025 the estimated population with diabetes will be...

Choroidal folds

Choroidal folds are undulations of the choroid, Bruch’s membrane and pigment epithelium, with wrinkling of the overlying retina. They may be idiopathic but can also be caused by a number of different conditions. Case report A 60-year-old male patient was...

Urban Changes and Rural Struggles for Ophthalmology in China

China is by far the most populated country in the world, with over 1.3 billion inhabitants. It is also the country with the highest number of blind and visually impaired people. As a developing country, half of China’s population lives...

Leber’s hereditary optic neuropathy: from lab to clinic

Leber’s hereditary optic neuropathy (LHON) was the first clinically described mitochondrial disorder (1871). This article reviews the pathophysiology and clinical features of LHON with a focus on translational research. G11778A is currently the most common mutation worldwide and is associated...

Informed consent in ophthalmology care in the UK: A critical component of patient‑centred practice

Informed consent is a cornerstone of ethical and legal practice in healthcare, particularly in fields like ophthalmology where specialised interventions can have significant implications for a patient’s vision and quality of life. In the UK, informed consent is not merely...

The results of the last survey Aug21

We are often referred patients noted to have an optic disc haemorrhage (ODH) without any other features of pathology. How we manage these patients can have a significant impact on our struggling capacity. The significance in glaucoma and, in particular,...