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ANGPTL-4 inhibition reduces inflammation in diabetic retinopathy
Diabetic retinopathy (DR) is the most common cause of blindness in working-age humans, and numbers are rising due to increased cases of type 2 diabetes (T2D). T2D is associated with increased obesity and dyslipidaemia, which is a major risk factor...
Long-term open angle glaucoma cohort study
This was a study to estimate the development of open angle glaucoma (OAG) in a screened and re-examined elderly group as compared to an unscreened group during the same time period. The participants comprised of 856 individuals born in 1915...
Visual acuity after cataract surgery in AMD patients
The data from this study are obtained from the Age-Related Eye Disease Study (AREDS) 2 and analysed to evaluate if cataract surgery benefits patients with concurrent age-related macular degeneration (AMD). The AREDS 2 was a five year, prospective, multi-centre randomised...
Correlation between structural and functional status of optic nerve and retina in multiple sclerosis
Multiple sclerosis (MS) involves autoimmune inflammatory demyelination and axonal degeneration in the central nervous system. Investigation of the retina and optic nerve head (ONH) is an ideal way to visualise this demyelination. This study investigates the functional and structural properties...
High-fluence collagen cross-linking
The authors treat seven eyes with progressive keratoconus with a high energy (18mW) for five minutes delivering a total energy similar to that suggested by the original Dresden protocol (3mW for 30mins). All eyes had a thickness >400µm following epithelial...
Use of the RAPDx device to evaluate efficacy of treatment in patients with optic nerve disease
The RAPDx objectively determines the RAPD magnitude by alternately presenting light stimuli to each eye and deriving amplitude and latency scores. The authors of this paper evaluated the amplitude and latency scores from the RAPDx together with other ophthalmic investigations...
Outcomes with small aperture IOLs
This study aimed to compare the clinical outcomes following the implantation of an extended depth of focus small-aperture intraocular lens (IOL) (IC-8; AcuFocus, Irvine, CA) for presbyopia correction when implanted monocularly or binocularly. Visual outcomes, defocus curve, patient satisfaction, and...
Corpus callosum in infantile esotropia
Diffusion tensor imaging (DTI) imaging was undertaken with four infantile esotropia (IE) patients and nine controls. All with IE showed an asymmetrical distribution of callosal fibres when comparing two hemispheres. Many fibres terminated near the tips of the occipital cortices....
The global burden of age-related macular degeneration
Age-related macular degeneration (AMD) is the third leading cause of blindness (behind cataract and refractive error). The authors present the results of the Global Burden of Disease (GBD) 2015 study, which included 195 countries. The disability-adjusted life years (DALY) due...
Is myopia protective against progression of diabetic retinopathy?
This population-based cohort study assessed the association of refractive error with the incidence and progression of diabetic retinopathy (DR); 1562 eyes of 860 patients with diabetes and gradable retinal photographs were included. Baseline data was taken between 2004-2009 and follow-up...
Use of Bagolini filter bars
The authors measured the percentage light transmission of filters on different Bagolini filter bars to evaluate whether a difference exists in density of suppression or strength of abnormal binocular single vision (BSV). A Sekonic dual spot photometer was used to...
