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Combined Vismodegib and Mohs surgery

This is a report of eight patients with locally advanced periocular basal cell carcinoma who were treated with Vismodegib prior to Mohs micrographic surgery. The rationale for the combined treatment plan was that long-term Vismodegib is poorly tolerated due to...

Prognostication for uveal melanoma

The authors highlight the importance of using all available data in the prognostication of uveal melanoma (UM). Over recent years a number of molecular tests have emerged to allow clinicians to predict metastatic potential of UM. However, concordance between techniques...

Presentation features of ocular neuromyotonia in children

The authors report five cases of ocular neuromyotonia (ON) in children following radiation treatment for brain tumours. Children were aged four, nine, twelve, five and nine years. Three had craniopharyngioma, one had fourth ventricle ependymoma and one had posterior fossa...

Pituitary tumours: why are they so often missed?

Part 2: Clinical varieties, anatomical considerations and case report (see also Part 1 and Part 3) For ophthalmologists there are four types of pituitary tumour to be considered, three of which are named according to the hormone secreted, along with...

Insights from the ‘Rb-NET Challenges’ Session: Evolving approaches in global retinoblastoma management

The Retinoblastoma Network (Rb-NET) Multidisciplinary Team (MDT) platform, developed by the London School of Hygiene & Tropical Medicine (LSHTM) and Professor Ido Didi Fabian, is a web-based telemedicine initiative that regularly hosts virtual MDT meetings focused on the evaluation and...

Nanoparticle administration of latanoprost

Glaucoma is a progressive optic neuropathy characterised by increased ocular pressure and loss of retinal ganglion cells. Conventional drug therapy with eye drops to reduce intraocular pressure (IOP) has variable bioavailability and can lead to ocular surface disease. In this...

Suspected vitreous seeding of uveal melanoma

This is a retrospective non-randomised study of 23 patients with consecutive uveal melanoma who underwent diagnostic vitrectomy between the period of January 2000 and November 2013. The reason for vitrectomy was suspected dissemination of tumour cells inside the eye. The...

PD-1 and PD-L1 in exenteration specimens

This is an immunohistochemical study looking at variation in the expression of the programmed death-1 receptor (PD-1) and the programmed cell death ligand-1 (PD-L1), comparing cutaneous malignancies which invaded the orbit with uncomplicated nodular basal cell carcinomas. The authors retrospectively...

Epidemiology of ocular cancer in Cali

The aim of this study was to describe the population trends of incidence and survival rates of ocular cancer in Cali, Columbia. Data was retrieved from the Registro Poblacion de Cancer de Cali (RPCC, i.e. Population Cancer Registry of Cali)...

Imaging and histological relationship of orbital Schwannomas

This is a retrospective review of 15 patients with orbital Schwannomas comparing the radiological characteristics, in particular the signal intensity on MRI, with the histological sub-types of the tumours. Five patients had MRI imaging alone, three had CT alone and...

Uveal melanoma

Uveal melanoma is the most common primary intraocular tumour. However, they are still rare, with an incidence of 2-8 per million [1]. The presence of a choroidal naevus is a risk factor for uveal melanoma [1]. Patients with choroidal lesions...

Portable vision reading device shows promise for low vision after brain injury

The authors report a small sample cohort study evaluating the impact of a portable vision reading device (OrCam Read) on vision-related quality-of-life and independent functional status in patients with low vision due to stroke or brain tumours. Six patients with...