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Importing iron to the retina

In the retina, iron is particularly critical for the visual phototransduction cascade. In the retinal pigment epithelium (RPE), RPE65 activity leads to 11-cis-retinaldehyde, the photosensitive component of rhodopsin production and iron containing enzymes are necessary for disc replacement in photoreceptor...

A relationship between central serous retinopathy and obstructive sleep apnoea

This prospective study aimed to evaluate a relationship between central serous retinopathy (CSR) and obstructive sleep apnoea (OSA). Twenty-three subjects (six female and 17 male) were diagnosed with CSR and overnight polysonography was performed to record desaturation and apnoeic episodes....

A missed intraocular telescope – an opportunity to re-focus the evidence

Intraocular telescopes allow magnification of the image so that it would be projected into a larger area of the macula, this makes the central defect caused by dry age-related macular degeneration (AMD) smaller. The most common approach is a Galilean...

Addressing medical risk factors for diabetes and understanding the new systemic treatments

As global diabetes figures continue to rise, the importance of reducing the burden of macrovascular and microvascular complications of diabetes has never been so great. By 2025 it is estimated that five million people in the UK will have diabetes...

Renewed momentum in ocular gene and cell therapy, broadening application to chronic disease

Gene and cell therapies offer the prospect of ground-breaking new avenues for the treatment of diseases, reflected in a renewed explosion of interest and investment in retinal gene therapy. Rod McNeil reports recent clinical trial readouts across a diverse range...

Imagination

"Logic will get you from A to B. Imagination will take you everywhere.” In this quote by Albert Einstein, he reminds us that whilst logic is useful for practical solutions, the expansive nature of imagination breaks boundaries. It can lead...

Assessing everyday visual function in dry AMD – what matters to the person?

Age-related macular degeneration (AMD) is the primary cause of blindness in the developed world and is accountable for more than one half of sight impairment registrations within England and Wales [1]. AMD is prevalent in people aged 60 years and...

Bridging the gap – Supporting our patients across the primary / secondary care divide

Providing the best care for patients is surely a fundamental goal for all healthcare professionals. When waiting-times are long and getting longer, clinics are full, colleagues are off with stress-related illness and patients are complaining, is it possible to still...

Beyond vision loss: Why doctors should know about Charles Bonnet Syndrome

Over 250 years have passed since Charles Bonnet’s seminal essay, in which he described the symptoms of the syndrome that now takes his name [1]. Charles Bonnet Syndrome (CBS) describes the occurrence of visual hallucinations in people with significant visual...

Hanson Wade: Dry AMD and Geographic Atrophy Therapeutics Summit 2025

Welcome to the 6th Dry AMD and Geographic Atrophy Therapeutics SummitTransformative Therapies for Dry, Intermediate & Late-Stage AMDWith late-phase trials advancing, novel mechanisms emerging, and global regulatory expectations evolving, the dry AMD and GA field is accelerating exponentially. Returning digitally...

Reflections on a twelve-year partnership: The Makassar-Dundee LINK

In the first article of a two-part series (see Part 2 here), the authors provide an overview of this hugely successful partnership and how they overcame the challenges of COVID-19. What began in 2008 as a connection between equals, has...

OSA regulatory advice baton moves to new expert

The OSA’s regulatory advice service – a key element of membership for many optical businesses – is moving to safe new hands as Ann Blackmore retires after six years at the helm. Ann’s extensive knowledge of the optical landscape, both...