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Retinal ganglion cell loss in diabetes and diabetic retinopathy

The aim of this observational case control study was to evaluate the association of diabetes and diabetic retinopathy (DR) with retinal ganglion cell loss. Cases were Chinese patients with type 2 diabetes with and without DR, aged 40-80 years. Eligible...

Familial Mediterranean Fever and keratoconus

This retrospective case control study was conducted in the Genetic Diagnostic Centre in Turkey. It examined the prevalence of keratoconus in two groups; patients with Familial Mediterranean Fever (FMF) and age matched controls free of FMF, who were tested for...

Reproducible OCT RNFL map in unilateral glaucoma

The aim of the study was to compare the reproducibility of the optical coherence tomography retinal nerve fibre layer (OCT RNFL) thickness map between glaucomatous and fellow normal eyes of unilateral glaucoma patients. The authors carried out a prospective case...

Ranibizumab for the treatment of age-related macular degeneration

This multicentre randomised prospective open label study compared 0.5 versus 2mg of ranibizumab in patients with submacular retinal pigment epithelial (RPE) detachment due to age-related macular degeneration. Four treatment regimens were used for the two strengths either monthly for 12...

Correlation between anti-retinal antibodies and proliferative vitreoretinopathy (PVR)

The pathological basis of PVR is not clearly understood and there are no effective medications targeting this condition. This cross-sectional study looked at the possible association of anti-retinal antibodies with patients with PVR and retinal detachment (RD). Aqueous and vitreous...

HtrA1 enhances cell senescence

A genetic basis for age-related macular degeneration (AMD) has been greatly advanced in recent years. The role of identified pathways such as complement factor H in AMD has been widely investigated. However, the effect of other gene variants identified by...

Long-term treatment of blepharospasm using Botulinum Toxin A

The authors report findings from a retrospective single-centre study which aimed to evaluate the efficacy and safety of long-term botulinum A toxin (BAT) treatment in patients with blepharospasm (BPS). Blepharospasm is described as one of the most frequent types of...

Effect of trabeculectomy on corneal endothelial cell loss

This is a prospective study of 117 eyes for two years after trabeculectomy, to investigate the corneal endothelial cell density (CECD) by specular microscopy prior to and after surgery on a six monthly basis. At six, 12, 18 and 24...

Information booklet for eye drop use

On the basis that children may be more at ease and experience less discomfort and anxiety if provided with some control and choices, the authors developed an eye drop booklet in collaboration with children. This study describes the amount of...

Comprehensive review of inherited retinal diseases

The authors offer an up-to-date review of inherited retinal diseases (IRDs). In each section the authors discuss the molecular basis of disease, genotype and clinical manifestation. They also discuss the investigation findings and current evidence in the treatment of the...

Oxymetazoline hydrochloride for improved symmetry in Graves’ disease

Oxymetazoline hydrochloride 0.1% ophthalmic solution has Food & Drug Administration (FDA) approval for use in involution ptosis. It is an alpha 1 agonist and partial alpha 2 agonist that stimulates Muller’s muscle to lift the lid. The authors of this...

RCT of surgery to correct asymmetrical DVD

This study compared the efficacy of two procedures: (1) bilateral symmetrical anteriorisation of the inferior oblique (AIO) and (2) combined resection and AIO, in cases of asymmetrical dissociated vertical deviation (DVD). This was a prospective randomised controlled trial including 54...