You searched for "litigation"
Lived experience with vernal keratoconjunctivitis (VKC)
5 August 2022
| Fiona Rowe (Prof)
This study was undertaken to explore the experience of living with VKC. Nine families were interviewed – paired interviews with patients and parents using semi-structured approaches (May-October 2018). Interviews continued until data saturation was reached with no new information. The...
Stereotactic radiotherapy for polypoidal choroidal vasculopathy
1 August 2015
| Sofia Rokerya
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EYE - Vitreo-Retinal
Polypoidal choroidal vasculopathy (PCV) is a variant of neovascular AMD. It is a disease of choroidal vasculature characterised by abnormal branching vascular network with aneurysmal dilatations (polyps). Features of PCV include pigment epithelial detachments (PED), subretinal fluid (SRF) accumulation and...
The Wachter Review
1 February 2017
| David Haider
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EYE - General
Professor Robert Wachter (pronounced Wokter) is well known in the NHS IT sector. In late 2015 Jeremy Hunt announced he had tasked Dr Wachter to lead a review of the digital future of the NHS. The resulting Wachter Review was...
Resveratrol protects against steroid induced intraocular pressure
1 April 2016
| Graham Wallace
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EYE - General
|
Glaucoma, Intraocular pressure, Resveratrol, Retina, Steroid-induced, Trabecular meshwork
Topical and systemic steroid delivery is a very effective treatment for many ocular conditions but is compromised by raised intraocular pressure which in turn leads to death of retinal ganglion cells and irreversible blindness. This is an important consideration with...
Differential inhibition of EAU by CTLA4 and IL-6
1 February 2016
| Graham Wallace
|
EYE - Vitreo-Retinal
Cytotoxic T lymphocyte antigen-4 (CTLA4) binds both CD80 and Cd86 and inhibits T lymphocyte activation via CD28. Il-6 is a pleiotropic cytokine that has been associated with many autoimmune conditions including uveitis. Blockade of these molecules by either CTLA4-Ig, a...
Statins inhibit TGFβ2 mediated fibrotic response in astrocytes
1 April 2018
| Graham Wallace
|
EYE - Glaucoma
Glaucoma is a common condition where increased ocular pressure can lead to death of retinal ganglion cells due to impaired drainage of fluid from the eye. One mechanism involved in glaucoma is remodelling of the extracellular matrix at the lamina...
Somatostatin protects retinal pericytes
1 April 2018
| Graham Wallace
|
EYE - Vitreo-Retinal
Diabetic retinopathy (DR) is a complication of diabetes, caused by high blood sugar levels damaging the retinal microvasculature. Mechanisms, such as oxidative stress and deposition of advanced glycation end products, leads to glial cell activation and neuronal apoptosis. Pericytes, contractile...
Cataract surgery and circadian photoentrainment
1 December 2015
| Brian Ang
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EYE - Vitreo-Retinal
The study authors sought to investigate the possible effects of circadian photoentrainment following cataract. This was a randomised clinical trial, where 76 eyes of 76 patients (with bilateral cataract) were randomised to blue-blocking or neutral intraocular lenses (IOLs). Outcome measures...
RPE use similar pathway to regulatory T cells to inhibit immune response
1 December 2014
| Graham Wallace
|
EYE - Vitreo-Retinal
Retinal pigment epithelial (RPE) cells form an important part of the blood-retinal barrier that protects the neuronal cells responsible for sight. RPE cells are involved in innate and adaptive immune responses via expression of surface molecules and release of cytokines....
Intravitreal functional plasminogen in branch retinal vein occlusion
1 December 2014
| Bheemanagouda Patil
|
EYE - Vitreo-Retinal
Branch retinal vein occlusion (BRVO) is the second most common vascular disorder of the eye. Intravitreal injections of anti-VEGF agents and corticosteroids have proven efficacy. Posterior vitreous cortex (PVC) adhesion has been shown to support the development of retinal vein...
Complement Factor H and Factor H-Like protein are expressed in human RPE cells
1 April 2014
| Bheemanagouda Patil
|
EYE - General
The role of inflammation in age-related macular degeneration (AMD) is well documented and the association of AMD with the inflammatory marker C-reactive protein (CRP) and members of the complement system underline the role of complements in AMD. Human complement factor...
Investigation of blood platelet parameters in anterior ischaemic optic neuropathy
1 August 2019
| Claire Howard
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EYE - Neuro-ophthalmology
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Anterior ischemic optic neuropathy, mean platelet volume, neutrophil to lymphocyte ratio, platelet distribution width, plateletcrit
The aim of this clinical retrospective comparative study was to assess the possible relationship between arteritic anterior ischaemic optic neuropathy (AAION) and non-arteritic anterior ischaemic optic neuropathy (NAION) with blood platelet parameters and neutrophil-to-lymphocyte ratio (NLR). The medical records of...