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Differential inhibition of EAU by CTLA4 and IL-6
Cytotoxic T lymphocyte antigen-4 (CTLA4) binds both CD80 and Cd86 and inhibits T lymphocyte activation via CD28. Il-6 is a pleiotropic cytokine that has been associated with many autoimmune conditions including uveitis. Blockade of these molecules by either CTLA4-Ig, a...
Limbal melanocytes and the stem cell niche
The cornea is continually regenerated to maintain clear vision, due to a population of stem cells located in the limbal region between the cornea and the conjunctiva. These limbal stem cells (LESC) reside in crypts in structures called the Pallisades...
Statins inhibit TGFβ2 mediated fibrotic response in astrocytes
Glaucoma is a common condition where increased ocular pressure can lead to death of retinal ganglion cells due to impaired drainage of fluid from the eye. One mechanism involved in glaucoma is remodelling of the extracellular matrix at the lamina...
A case report of alternating anisocoria with associated nasal congestion
The authors have described a group of healthy individuals who show alternating anisocoria, in a previous paper. In these cases, the pupil asymmetry alternates between eyes every few hours, with no observed instances when both pupils are equal in size....
Could medical cannabis be used to successfully treat blepharospam?
This study observed the effect of medical cannabis in benign essential blepharospasm (BEB), in addition to standard botulinum toxin treatment. The study comprised of a retrospective chart review on eligible patients and included information on patient demographics, responses, cannabis history...
Association between colour vision impairment and amyotrophic lateral sclerosis (ALS)
The purpose of this study is to test the hypothesis that colour vision impairment is associated with amyotrophic lateral sclerosis (ALS). Abnormalities of the inner and intermediate retinal structures in patients with ALS have been described using optical coherence tomography...
Marcus Gunn jaw winking without ptosis
This is a review of 72 cases of Marcus-Gunn jaw winking syndrome. The authors reviewed all their congenital ptoses seen over a 16 year period and found 72 Marcus-Gunn cases of out of a total of 848 patients. Within the...
Outcomes of Hughes flap in lower eyelid reconstruction
One hundred and 22 consecutive patients who underwent tarsoconjunctival advancement flap surgery for lower eyelid defects were part of this study. Ninety percent of them had lesion excision using Mohs micrographic surgery. Eighty percent of these were for basal cell...
Visual field changes in thyroid eye disease (TED)
This study is a retrospective non- comparative review of visual field (VF) tests in patients with compressive optic neuropathy from thyroid eye disease (TED-CON). Ninety-six visual fields in 68 patients were included in the study and a two-step analysis of...
Blepharokeratoconjunctivitis treatment consensus
This study reports the results of a Delphi consensus method to develop a pragmatic approach to BKC treatment in children. A major limitation to the study was the involvement of only four clinicians. Four rounds in total were completed to...
IOP measures after intraocular chemotherapy
This study aimed to describe the relationship between intravitreal chemotherapy and IOP in children with retinoblastoma and identify risk factors for pronounced elevations. This was a retrospective study of ten cases (ten eyes) with 17 encounters overall. Mean age was...
