You searched for "IgG4"
Proptosis reduction with teprotumumab versus surgical decompression
This study aims to explore whether fat-to-muscle ratio (FMR) can be used to determine the efficacy of teprotumumab when compared to surgical decompression. Simply put, a high FMR equates to more fat expansion and low FMR equates to more muscle...
Correlation between anti-retinal antibodies and proliferative vitreoretinopathy (PVR)
1 October 2018
| Kurt Spiteri Cornish
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EYE - Vitreo-Retinal
The pathological basis of PVR is not clearly understood and there are no effective medications targeting this condition. This cross-sectional study looked at the possible association of anti-retinal antibodies with patients with PVR and retinal detachment (RD). Aqueous and vitreous...
Atlas Of Orbital Imaging
It was an absolute pleasure to review this beautifully written textbook. Authorship is from a diverse, international group of experienced and respected oculoplastic surgeons with an interest in orbital disease. A significant contribution to most of these chapters has been...Old dogs
3 April 2023
| Baljean Dhillon (Prof)
It is always nice to get a thank you card, especially so when it comes from someone at the tail end of an overbooked clinic who had waited patiently well past their appointed slot. Such was the case when I...
Review of pathogenesis of Acanthamoeba keratitis
In this review, the author summarised the current microbiomic and immunological evidence related to the pathogenesis of Acanthamoeba keratitis (AK). AK has been described for almost 50 years, but the exact biology of the disease remains perplexing. Acanthamoeba spp. are...Cutting-edge practice in glaucoma care: what, how and why?
1 April 2016
| Nick Strouthidis, Winifred Nolan, Keith Barton
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EYE - Glaucoma
More effective treatments and drug delivery modalities, implantable minimally invasive glaucoma surgical (MIGS) devices, as well as accelerating clinical research programmes, will transform the surgical and clinical management of glaucoma in the near future. There is also an ever-greater emphasis...
Coeliac disease and anterior scleritis
The authors present an interesting case report of recurrent anterior scleritis. Circulating IgA and IgG auto-antibodies directed against tissue transglutaminase, endomisium and gliadin are frequently elevated in patients with coeliac disease. The classic symptoms remain chronic diarrhoea, malabsorption syndromes and...Acute retinal necrosis presumably caused by Epstein-Barr virus infection
1 October 2015
| Antigoni Koukkoulli, Mark Cachia Markman, Anindita Homchoudhury, Oliver Backhouse
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EYE - Cataract, EYE - Cornea, EYE - General, EYE - Glaucoma, EYE - Imaging, EYE - Neuro-ophthalmology, EYE - Oculoplastic, EYE - Oncology, EYE - Orbit, EYE - Paediatrics, EYE - Pathology, EYE - Refractive, EYE - Strabismus, EYE - Vitreo-Retinal
Acute retinal necrosis (ARN) is an uncommon, but serious and potentially blinding condition. ARN is characterised by panuveitis, occlusive vasculopathy and progressive peripheral necrotising retinitis. The diagnosis is clinical but confirmation is sought via aqueous and vitreous sampling. Varicella zoster...
Blurred vision post liver transplant: to blame the house cat or not?
1 October 2014
| Stephenie Tiew, Gideon Hirschfield, Ian Pearce, Nicholas Beare
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EYE - Cataract, EYE - Cornea, EYE - General, EYE - Glaucoma, EYE - Imaging, EYE - Neuro-ophthalmology, EYE - Oculoplastic, EYE - Oncology, EYE - Orbit, EYE - Paediatrics, EYE - Pathology, EYE - Strabismus, EYE - Refractive, EYE - Vitreo-Retinal
This article outlines a case of atypical ocular toxoplasmosis associated with immunosuppression. There were two potential sources of infection in this patient and we describe how we concluded which was the most likely. Case report A 33-year-old female was referred...
Paraproteinaemia: a patient with atypical corneal findings
A Bence Jones protein is a monoclonal globulin protein or immunoglobulin light chain found in the urine, with a molecular weight of 22-24 kDa [1]. Detection of Bence Jones protein may be suggestive of multiple myeloma or Waldenström’s macroglobulinemia. Multiple...Friendly felines and a spot diagnosis
1 June 2014
| Jonathan Park
|
EYE - Vitreo-Retinal
A nine-year-old girl presented to me in eye casualty with a three-week history of blurred vision in her left eye. Otherwise she was apparently well, with no past ophthalmic, medical, drug or relevant family history. Visual acuity was 6/4 right...
Crystalline keratopathy in monoclonal gammopathy of undetermined significance
2 April 2025
| Kar Yen Phoong
|
EYE - Cornea
Monoclonal gammopathies encompass a group of plasma cell disorders characterised by the excessive production of abnormal monoclonal immunoglobulins in the bloodstream [1]. This category includes multiple myeloma, monoclonal gammopathy of undetermined significance (MGUS), amyloidosis and other lymphoproliferative disorders. Monoclonal gammopathy...
