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Retinoblastoma chemotherapeutic drugs and their toxic effects on RPE cells

1 October 2016 | | EYE - Vitreo-Retinal
There is reported clinical evidence of retinal pigment epithelium (RPE) alterations after intra-arterial (IAC) and intravitreal chemotherapy (IViC) of retinoblastoma. The purpose of this study was to investigate the cellular toxic effects of melphalan, topotecan and carboplatin on the RPE...

Penetrating keratoplasties in infants

1 August 2016 | | EYE - Cornea, EYE - General
This retrospective review looked at endothelial cell counts (ECC) following penetrating keratoplasties (PKP) performed in infants within the first year of their life. One hundred eyes of 71 patients had their first PKP during the study period (1998-2013). In 30%...

Transfected RPE cells inhibit AMD in rats

1 August 2015 | | EYE - Vitreo-Retinal
Age-related macular degeneration (AMD) is a leading cause of blindness in the elderly. Wet AMD is characterised by choroidal neovascularisation, new vessels into the retina, leading to leakage and tissue damage. Many proangiogenic factors particularly vascular endothelial growth factor (VEGF)...
British Journal of Ophthalmology cover image.

Long-term effect of YAG LPI on corneal endothelium in PACS

4 August 2021 | | EYE - Cornea, EYE - General
This is a single-centre randomised controlled trial of 875 patients with bilateral primary angle closure suspect (PACS) who received YAG laser iridotomy (LPI) prophylactic treatment in one eye randomly and the fellow eye served as control over 72 months. Central...

Medial rectus anatomy in exotropia

1 October 2021 | | EYE - Paediatrics, EYE - Strabismus
This study investigates the differences between extraocular muscles in patients with intermittent exotropia and normal controls regarding muscle fibre arrangement and diameter, and distribution and activation of satellite cells. Fifteen patients were recruited having medial rectus resection surgery. Resection sections...
Seminars in Ophthalmology journal cover image

Does lower eyelid entropion repair alter corneal topography?

1 February 2022 | | EYE - Cornea, EYE - General
The authors aimed to analyse the corneal morphology before and after advancement of posterior lower eyelid retractors (LERs) alone or in combination with a lateral tarsal strip (LTS) for lower eyelid involutional entropion. Retrospective analysis of 24 consecutive elderly patients...

Changes in corneal endothelial layer after strabismus surgery

5 April 2022 | | EYE - Paediatrics, EYE - Strabismus
The purpose of this study was to investigate the changes in the corneal endothelial layer by specular microscopy after surgery in patients with horizontal and oblique strabismus. Eighty-three eyes of 56 patients were evaluated prospectively. There were three subgroups: one...

A standardised strategy for uveitis etiological diagnosis

1 August 2017 | | EYE - Vitreo-Retinal
This was a prospective, non-inferiority, multicentre randomised control trial, which aimed to assess the effectiveness of a standardised approach in the etiological diagnosis of uveitis versus an open strategy, where clinicians could perform any test. The authors developed their standardised...

Upper eyelid ulceration as a presenting sign of frontal sinus mucocele

3 October 2022 | | EYE - General
Introduction A sinus mucocele is an epithelium-lined sac filled with mucus and desquamated epithelium. It forms secondary to inflammatory processes that occur in a sinus with an obstructed ostium. Predisposing conditions include previous trauma, surgery, tumours, anatomical abnormalities, and chronic...

The management of possibly progressive pterygium

1 February 2015 | | EYE - Cornea
A 43-year-old Sudanese male patient is referred by his GP with a fleshy lesion encroaching the nasal cornea for the last six months. History Make note of: risk factors, i.e. UV exposure and ocular irritation - history of living in...

Ocular electrophysiology

1 April 2014 | | EYE - Oculoplastic, EYE - Orbit
A 34-year-old woman, who is a CEO in a multinational firm, has been losing vision over the last 12 months. She has seen her opticians, who initially tried different glasses but could not improve things. Clinical examination is unremarkable. How...

Time is vision in central retinal artery occlusion

4 August 2021 | | EYE - Vitreo-Retinal, EYE - General
Central retinal artery occlusion (CRAO) is a rare but devastating vascular episode that can have severe impact on vision. Treatment is very time-limited and needs to be initiated very quickly to salvage any vision. The majority of patients present to...