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Neurofibromatosis with multiple bilateral choroidal nevi and literature review
The aim is to present a case of neurofibromatosis type-1 (NF-1), also known as von Recklinghausen disease, who presented with bilateral multiple choroidal nodular nevi following chemotherapy and mastectomy for breast cancer. Neurofibromatosis type-1 presents as a wide range of...Moorfields: Laser Course
Moorfields Education: Laser course for ophthalmic healthcare professionalsWhat’s Eating Gilbert Pete
“Please phone Mr C Lyon ASAP on 0131 334 9171” This was a message from my secretary waiting for me on my computer one morning shortly after I was appointed a consultant. The name did not ring any bells but...Moorfields DALK wet lab
Deep Anterior Lamellar Keratoplasty (DALK) is the most challenging technique of corneal transplantation. Moorfields Eye Hospital performs a high volume of DALK surgeries and is currently the leading centre in corneal transplantation in Europe. The Moorfields DALK wet lab, delivered...Choroidal melanoma – breaking bad news
Case report A 55-year-old Caucasian female presented to her general practitioner with a three-month history of headaches and worsening blurred vision in the left eye. On further close questioning, she reported no eye pain, intermittent floaters and flashes of light...
A mouse model for uveal melanoma
Uveal melanoma (UM) is the most common malignant tumour arising within the eye and is a severe threat for both sight and life, due to a high risk of metastasis. There are no animal models of UM, but the Tg(Grm1)...
Melphalon treatment of retinoblastoma
The purpose of this study was to report the authors’ experience with superselective ophthalmic artery infusion of Melphalon (SOAIM) for the treatment of five cases of unilateral sporadic retinoblastoma involving the macula. Standard therapy included a cycle of three infusions...
Reduction of severe visual loss and complications following IAC for RB
This was a retrospective cohort study of patients with retinoblastoma (RB) who required intra-arterial chemotherapy (IAC) between 2013 and 2015, who had relapsed following systemic chemotherapy. A total of nine patients were included in the study and their ocular complications...
HtrA1 enhances cell senescence
A genetic basis for age-related macular degeneration (AMD) has been greatly advanced in recent years. The role of identified pathways such as complement factor H in AMD has been widely investigated. However, the effect of other gene variants identified by...
Prevalence of strabismus in neurofibromatosis type 1
The purpose of this study was to evaluate the prevalence of strabismus in NF1 by comparing children with normal neuroimaging to those with optic pathway glioma. The study included 236 children with NF1, of which 38 were excluded with no...
Diffuse lamellar keratitis
This study group reviewed cytokine- and chemokine-mediated mechanisms of diffuse lamellar keratitis (DLK) after lamellar corneal surgical procedures. DLK can occur early or late (months to decades) after all lamellar corneal surgeries, including laser in situ keratomileusis, small incision lenticule...
