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Treatment of Sjogren’s Syndrome dry eye in mouse model
Sjogren’s syndrome (SS) is a chronic autoimmune disease characterised by inflammation of the exocrine glands, specifically the salivary and lacrimal glands that produce saliva and tears, respectively. The immune-mediated attack on the salivary and lacrimal glands leads to the development...
Wide variation in the volume of the sphenoid trigone
This is a radiological study of the volume of the sphenoid trigone in normal subjects. The authors were interested to see how much volume could be gained by removal of the trigone during an orbital decompression for thyroid eye disease....
Autophagy in lens mitochondria loss
The lens consists of a monolayer of epithelial cells that overlies fibre cells that differentiate from epithelial cells at the equator. While developing, fibre cells need mitochondria to provide energy, as they mature they lose these and other organelles to...
Therapeutic ocular surface medium for persistent corneal epithelial defect
Corneal ulcers and persistent epithelial defects (PEDs) are caused by a variety of different insults to the cornea, which includes limbal epithelial stem cell failure. PED may be resistant to healing with standard therapy such as frequent ointments and /...
Corneal neurotisation with an allograft
This is the first reported use of an acellular nerve allograft for corneal neurotisation. Seven patients received a 7cm long commercially prepared acellular nerve allograft. This was coapted to a functioning supratrochlear, supraorbital or infraorbital nerve and then tunnelled to...
Wrong-site surgery
A survey was undertaken with paediatric ophthalmologists to assess a set of factors that influence the risk of wrong-site surgery. The survey specifically considered the preoperative marking process and time-out procedure. It looked at factors included or not included in...
Factors leading to loss to follow-up after strabismus surgery in children.
One hundred and fourteen patients were identified as lost to follow-up between 2014 and 2020, representing 16% of paediatric strabismus surgery performed during this time period. The authors specifically defined lost to follow-up as not attending follow-up appointments between three...
Computer-assisted surgery in the orbit
In this paper the authors describe the growing use of computer-assisted surgery in ophthalmology. It is already described as a powerful adjunct in neurosurgery and sinus surgery and here they describe their experience of using it for the orbit; specifically...
Features of childhood cases of sixth nerve palsy
Based on limited information available for cranial nerve palsies in children, the authors aimed to collect data on new onset paediatric sixth nerve palsies in a UK population. This was a retrospective study over 10 years for children aged <18...
Tocilizumab in Graves’ orbitopathy
This prospective European study looks at the response to tocilizumab in corticosteroid-resistant disease. Tocilizumab (TCZ) is a monoclonal antibody that competitively inhibits IL-6 binding to its receptor. Unlike teprotumumab, the advantage of TCZ is that it is already used within...
Natural history of optic nerve head drusen in a paediatric population
A retrospective case notes review is presented focusing on children diagnosed with optic nerve head drusen over an eight-year period. Inclusion criteria included cases coded for optic nerve head drusen and / or pseudopapilledema. The aim of the study was...
