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Feb/Mar 2017 Quiz
History A 40-year-old male patient presented with a right lower eyelid swelling with gradual enlargement for two months. On examination there was a large lesion apparently involving lid margin, part of palpebral conjunctiva and skin. No other local or systemic...The butterfly effect
One of the most fascinating aspects of being a consultant is seeing the workings of the machine that is medical training from the other side. For two years now I have taken part in the specialty recruitment interviews and it...
Germline mutation risk in solitary unilateral retinoblastoma
This study aimed to determine the true risk for germline mutation in a child presenting with solitary unilateral RB and whether this risk differs by age at presentation. This was a retrospective review of 482 cases from 1972-2020. Age groups...Immunoglobulin G4-related ophthalmic disease – what is it? (Part 1)
Part 1: Epidemiology, classification, radiology, histopathology and associations (see Part 2 here) In this two-part series, Li Yen Goh reviews IgG4 disease and reminds us of diagnostic challenges faced. Introduction Immunoglobulin G4 (IgG4) disease is a recently recognised idiopathic systemic...
Longitudinal findings in children with neurofibromatosis type 1
This retrospective chart review evaluates the ophthalmologic findings of children with neurofibromatosis type 1 (NF1). Optic pathway gliomas (OPGs) are the most common tumours found in children with NF1. Findings are compared between eyes with and without optic pathway gliomas...
Treatment of Sjogren’s Syndrome dry eye in mouse model
Sjogren’s syndrome (SS) is a chronic autoimmune disease characterised by inflammation of the exocrine glands, specifically the salivary and lacrimal glands that produce saliva and tears, respectively. The immune-mediated attack on the salivary and lacrimal glands leads to the development...
Migraine attack: does retinal and peripapillary blood flow change?
This prospective clinical study compared retinal and peripapillary blood flow parameters in migraine patients during an attack with healthy controls using optical coherence tomography angiography (OCTA). OCTAs were performed on 52 eyes from 26 migraine sufferers and 48 eyes from...
OCT angiography metrics in children
This prospective study aimed to quantify the vessel density of both the macular and optic nerve and foveal avascular zone (FAZ) values in 92 normal eyes of 92 children (42 boys, 50 girls) aged 13.4 ±2.65 years (seven to 18)....
A standardised strategy for uveitis etiological diagnosis
This was a prospective, non-inferiority, multicentre randomised control trial, which aimed to assess the effectiveness of a standardised approach in the etiological diagnosis of uveitis versus an open strategy, where clinicians could perform any test. The authors developed their standardised...
