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2214 results found

The prevalence of macular cysts in patients with clinical cone-rod dystrophy determined by spectral domain optical coherence tomography

Cone-rod dystrophy is a progressive photoreceptor disorder which has multiple inheritance patterns. It is rare, with a prevalence of 1 in 40,000. Macular cysts are well recognised in other photoreceptor conditions such as retinitis pigments and choroideraemia, while they are...

Autophagy in lens mitochondria loss

The lens consists of a monolayer of epithelial cells that overlies fibre cells that differentiate from epithelial cells at the equator. While developing, fibre cells need mitochondria to provide energy, as they mature they lose these and other organelles to...

Enzymatic clearance of anterior chamber infiltrate in uveitis

Aqueous humour (AH) which fills the anterior chamber (AC) of the eye provides nutrients to the cornea and the lens. Clearance of cellular and particular matter from AH is necessary for good visual acuity. In part this is achieved by...

Microperimetry of subretinal drusenoid deposits

Subretinal drusenoid deposits (SDD), originally termed ‘reticular pseudo-drusen’, have recently been identified by histology and optical coherence tomography (OCT) as aggregations located in the subretinal rather than the sub retinal pigment epithelium (RPE) space. These deposits affect the amount of...

Nanoparticle administration of latanoprost

Glaucoma is a progressive optic neuropathy characterised by increased ocular pressure and loss of retinal ganglion cells. Conventional drug therapy with eye drops to reduce intraocular pressure (IOP) has variable bioavailability and can lead to ocular surface disease. In this...

Diclofenac versus Bromfenac after cataract surgery

Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used after cataract surgery to reduce inflammation and cystoid macular oedema (CMO). Diclofenac 0.1% is used three to five times daily for 28 days and Bromfenac 0.09% twice daily for 14 days postoperatively. The...

Laser pointer maculopathy

The objective of this study was to describe the potential clinical presentations of retinal pathology resulting from exposure to laser pointers. The study included eight eyes of seven patients. Mean age was 18.7 years (12-36). Most were accidental self-inflicted while...

Association between diabetes mellitus and dry eye disease

Diabetes mellitus (DM) is currently one of the most prevalent chronic diseases in the United States. It is estimated that 12.3% of Americans suffer from DM. In this study the authors compare between dry eye and diabetes mellitus among a...

Perceptual learning treatment for amblyopia

The authors previously conducted a feasibility study examining the potential benefit of a self-administered at-home use of a tablet-based perceptual learning (PL) game. Visual stimuli were presented in various orientations and spatial frequency in a game-play format. This study evaluates...

Caffeine concentration in the vitreous after drinking coffee

Caffeine is known to penetrate many bodily fluids, including the vitreous. In this prospective study, investigators measured caffeine levels in vitreous samples from patients undergoing vitrectomy and epiretinal membrane peel. Patients were divided into habitual and non-habitual coffee drinkers. One...

Subconjunctival anaesthesia in vitreoretinal surgery

The authors present a technique that combines topical and subconjunctival anaesthesia for vitreoretinal surgery. In this ‘two-step’ procedure, three drops of proparacaine were applied to the conjunctival fornix, followed by subconjunctival lidocaine injected in three quadrants. This was compared with...

Dead bag syndrome: a new and rare cause of late IOL dislocation

The dead bag syndrome has recently been described as a cause of late spontaneous intraocular lens (IOL) subluxation and / or dislocation. The capsular bag remains clear years after surgery and then becomes diaphanous and floppy. The authors explanted seven...