This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies.  Read our Cookies Policy.
Close
Eye News
  • Features
    • Close
    • Features
    • Allied Professions
    • Humanitarian
    • Interviews
    • AI & Oculomics
    • Ophthalmology
    • Optometry
    • Podcast videos
    • Supplements
  • Education
    • Close
    • Education
    • Learning Curve
    • Quiz
    • Top Tips
    • Trainees
    • Medico-Legal
    • The Truth Behind The Headlines
    • Case Reports
    • Pete's Bogus Journey
  • Reviews
    • Close
    • Reviews
    • Book Reviews
    • Journal Reviews
    • What's trending?
    • Tech Reviews
    • My Top Five
    • The Culture Section
  • Events
  • News
  • Product Guide
  • Industry News
  • Contact us
    • Close
    • Contact us
    • Write for Eye News
  • Home
  • Reviews
  • Journal Reviews
  • Tocilizumab in Graves’ orbitopathy

Tocilizumab in Graves’ orbitopathy
Reviewed by Hetvi Bhatt

2 February 2024 | Hetvi Bhatt | EYE - Oculoplastic, EYE - Orbit
Share This

This prospective European study looks at the response to tocilizumab in corticosteroid-resistant disease. Tocilizumab (TCZ) is a monoclonal antibody that competitively inhibits IL-6 binding to its receptor. Unlike teprotumumab, the advantage of TCZ is that it is already used within the NHS and other healthcare systems and has a lower financial burden. The number of study participants is small (n=10), however the authors state that TCZ resulted in a mean clinical activity score (CAS) reduction of 4.5 ± 1.2 and also resulted in a significant decrease in thyroid-stimulating immunoglobulin. One patient with sight threatening Graves’ orbitopathy (GO) did require orbital decompression, but the authors comment that in retrospect they may have been able to delay the decision to operate until the second infusion of TCZ. There are a number of steroid-sparing agents under investigation for the treatment of GO. Given that IL-6 plays an important role in activating orbital fibroblasts, a treatment specifically targeting this pathway seems logical. Whether it proves beneficial in practice, only time will tell.

Treatment of corticosteroid-resistant Graves’ orbitopathy with tocilizumab: a single-centre prospective study.
Dorado Cortez O, Grivet D, Perrillat N, et al.
ORBIT
2023;42(4):411-7.
Share This
CONTRIBUTOR
Hetvi Bhatt

Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK.

View Full Profile
Specialty
  • EYE - Cataract
  • EYE - Cornea
  • EYE - General
  • EYE - Glaucoma
  • EYE - Neuro-ophthalmology
  • EYE - Oculoplastic
  • EYE - Oncology
  • EYE - Orbit
  • EYE - Paediatrics
  • EYE - Pathology
  • EYE - Refractive
  • EYE - Strabismus
  • EYE - Vitreo-Retinal
Archive
  • 2025
  • 2024
  • 2023
  • 2022
  • 2021
  • 2020
  • 2019
  • 2018
  • 2017
  • 2016
  • 2015
  • 2014
  • 2013

Top Of Page

9 Gayfield Square, 
Edinburgh EH1 3NT, UK.

Call: +44 (0)131 557 4184
www.pinpoint-scotland.com

WEBSITE DETAILS
  • Cookie Policy
  • Data Protection Notice
  • Privacy Policy
  • Terms and Conditions
ABOUT US
  • Who we are
  • Register
  • Contact us
  • Contributors
  • Company Awards
DIGITAL ISSUES/GUIDELINES
  • Digital issues - Library
  • Supplements - Library
  • Guidelines
Accreditations
IPSO_FLAG_TEAL 2025.png cpdcertified.png

Pinpoint Scotland Ltd (Registered in Scotland No. SC068684) | © 2025 - Website by Gecko Agency