PAX7 is a transcription factor and is expressed in non-active and activated satellite cells. It is needed for muscle progenitor function, survival and expansion. This study investigates the effect of recession/resection surgery on PAX7-positive satellite cells in extraocular muscles of 20 rabbits (10 superior rectus recession and 10 superior rectus resection: inferior rectus as agonist muscle and contralateral unoperated superior rectus as control). Mean value of PAX7 positive satellite cells in operated muscles was 5.61 ±1.83 pixels percent (P%). Samples were taken at 4 weeks post-surgery. Mean numbers for agonist and control muscles were 2.82 ±1.13 and 1.25 ±0.16P% which were significantly different to the operated muscle. The mean for superior rectus recession was 3.86 ±0.43P%; significantly lower than for superior rectus resection (7.37 ±0.26P%). The mean for the agonist muscle for recession was 1.77 ±0.25P%; significantly lower than the agonist for resection (3.88 ±0.42P%). There were non-significant differences for recessions of 5 vs 10mm for operated and agonist muscles, and the same for resections of 4 vs 8mm. The authors conclude the extent of extraocular muscle regeneration may vary dependent on the method of strabismus surgery and may influence surgical outcomes.
Investigation of PAX7 positive satellite cells in extraocular muscle surgery
Reviewed by Fiona Rowe
Changes in PAX7 positive satellite cells in extra ocular muscles after strabismus surgery.
CONTRIBUTOR
Fiona Rowe (Prof)
Institute of Population Health, University of Liverpool, UK.
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