This is the first study to evaluate the choroidal thickness in patients with ocular sarcoidosis during the quiescent phase using enhanced depth imaging optical coherence tomography (EDI-OCT) and comparing with normal subjects. Ocular sarcoidosis may affect the choroidal circulation (occlusive arteriolitis) which may induce the reduction of the choroidal thickness. During the inflammatory phase the thickness of the choroid may change. The study included 18 eyes of nine patients with ocular sarcoidosis (eight women and one man mean age 59 years +/-18.5) and their subfoveal choroidal thickness was measured using EDI-OCT and compared to the age, sex and spherical equivalent-matched normal subjects. The mean subfoveal choroidal thickness was 281.76+/- 88µm in patients with sarcoidosis and 432+/-71µm in controls. Significant differences were found at points between the nasal 1500µm and temporal 1000µm to the fovea between patients and control group (p=0.002 at fovea). Therefore, the patients with sarcoidosis had thinner choroidal layer in the quiescent phase when compared to control subjects.