MRI characteristics of NMO, MOG and MS-related ON
3 June 2021
| Su Young
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EYE - Neuro-ophthalmology
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MRI, Optic nerve, multiple sclerosis (MS), myelin oligodendrocyte glycoprotein antibody disease (MOG-AD), neuromyelitis optica (NMO), optic neuritis
This review article examined differences of MRI appearances that can help clinicians assess and manage these important neuro-ophthalmic disorders. It also examined the role of optic nerve MRI as a prognostic indicator in acute optic neuritis (ON). The major findings...
Effects of idiopathic intracranial hypertension on the optic nerves
7 April 2021
| Claire Howard
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EYE - Neuro-ophthalmology
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Optic nerve, idiopathic intracranial hypertension, papilloedema
The authors review the latest evidence regarding how the optic nerves are affected by idiopathic intracranial hypertension (IIH), possible pathophysiology and methods of assessment. IIH is described as a clinical syndrome of raised intracranial pressure of unknown aetiology. A systematic...
Relationship between intraocular pressure and optic nerve damage in optic nerve drusen
7 April 2021
| Claire Howard
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EYE - Neuro-ophthalmology
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Optic nerve head drusen, intraocular pressure, retinal nerve fibre layer, visual field
The authors present a retrospective study exploring the relationship between intraocular pressure (IOP) and optic nerve damage in patients with optic nerve drusen. The aim was to evaluate if patients with normal ocular pressure at the time of optic nerve...
PD-1 and retinal ganglion cell death
1 February 2016
| Graham Wallace
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Apoptosis, Large retinal ganglion cells, Neuroprotection, Optic nerve crush, Programmed cell death-1
Death of retinal ganglion cells (RGC) in conditions like glaucoma leads to permanent visual loss. RGC death can be due to the initial stress such as raised intraocular pressure or secondary to mechanism such as oxidative stress. Programmed cell death-1...
