Corneal stroma modelling under hypoxic conditions
1 August 2018
| Graham Wallace
|
EYE - Cornea, EYE - General
|
Confocal fluorescence microscopy, Cornea, Corneal organ culture, Extracellular matrix, Stroma
The cornea is exposed to hypoxia under several conditions including sleep, inflammation and wound healing. Being an avascular tissue to maintain transparency, how the cornea homeostatic controls oxygen tension is important. To address this process two models were utilised; a...
Stromal cell alignment in damaged cornea
1 August 2017
| Graham Wallace
|
EYE - Cornea, EYE - General
|
Confocal microscopy, Corneal wound healing, Extracellular matrix, SHG imaging
Stromal keratocytes are responsible for wound healing in the cornea following damage. Keratocytes at the site of injury become activated and differentiate to myofibroblasts which secrete extracellular matrix (ECM) to close the wound, a response mediated by transforming growth factor...
