Retrospective analysis on the outcomes of contact lens-associated keratitis in a tertiary centre
Reviewed by Jonathan Chan

This is a retrospective cohort study of 161 eyes (153 patients) with contact lens-associated keratitis (CLAK) from Moorfields Hospital between 1 July 2021 to 28 February 2022. They were classified into three groups based on the size of the epithelial defect size (grade 1: <1.0mm; grade 2: 1–2mm; grade 3: >2mm). Risk factors, clinical findings, treatments and outcomes were studied. Grade 1 and 2 defects of CLAKs have excellent outcomes following empirical fluoroquinolone treatment and can be safely discharged with 96% within 48 hours and 94.1% within two weeks respectively. Grade 3 CLAK defects require prolonged duration of treatment. The most significant risk factors are extended-wear CL, poor hygiene and prolonged duration of wear. The authors concluded that the management protocol would reduce the number of unnecessary reviews in 68.9% (n=111) of all CLAKs. Grade 3 and atypical features require monitoring for resolution, further diagnostics or treatment.

Retrospective analysis on the outcomes of contact lens-associated keratitis in a tertiary centre: an evidence-based management protocol to optimise resource allocation.
Cai Y, Clancy N, Watson M, et al.
BRITISH JOURNAL OF OPHTHALMOLOGY
2025;109:21–6.