Brolucizumab in age-related macular degeneration, HAWK Study
3 October 2023
| Kurt Spiteri Cornish
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EYE - Vitreo-Retinal
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Neovascular age-related macular degeneration, aflibercept, anti-vascular endothelial growth factor therapy, brolucizumab, commercial formulation
The aim of the study was to collect additional data on efficacy and safety of brolucizumab 6mg intended for commercialization in age-related macular degeneration (AMD) (with an increase in pH and decrease in polysorbate concentration). The HAWK Study was a...
Effect of heredity on risk of diabetic retinopathy
1 September 2023
| Kurt Spiteri Cornish
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EYE - Vitreo-Retinal
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Diabetic macular edema, heredity, proliferative diabetic retinopathy, risk factors, survival analysis
This study used survival analysis on 2199 patients who had reached vision-threatening diabetic retinopathy to investigate the contribution of heredity to diabetes together with other known risk factors for the development of either proliferative diabetic retinopathy (PDR) or diabetic macular...
Association between neurodegeneration and macular perfusion in the progression of diabetic retinopathy
9 August 2023
| Sofia Rokerya
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EYE - Vitreo-Retinal
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Diabetes, Neurodegeneration, Progression, Retinopathy, Vessel closure
In this prospective three-year longitudinal study, the authors aimed to explore the relation between retinal neurodegenerative changes and vessel closure (VC) in individuals with non-proliferative diabetic retinopathy (NPDR). The participants included 74 individuals with type 2 diabetes, NPDR, and Early...
Silicone oil (SOT) versus gas (GT) tamponade for primary rhegmatogenous retinal detachment treated successfully with a propensity score analysis
3 August 2023
| Jonathan Chan
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EYE - Vitreo-Retinal
This is a retrospective, nationwide, multicentre study with retinal detachment (RD) in the Japan-RD Registry between 2016 to 2017. The primary outcome was the estimated mean difference of postoperative cerebral vascular accident (CVA) in six months and a propensity score...
Environmental variations in endophthalmitis
3 August 2023
| Kurt Spiteri Cornish
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EYE - Vitreo-Retinal
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Endophthalmitis, anti-VEGF, climate, intravitreal injection, season
In this retrospective cohort study, the authors looked at seasonal and environmental variations in 171 endophthalmitis cases out of 423,297 intravitreal injections. The incidence of this complication was not correlated to monthly snowfall, rainfall, or average temperature. There was no...
OCT prognostic factors in AMD patients with peripapillary choroidal neovascularisation
3 August 2023
| Sofia Rokerya
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EYE - Vitreo-Retinal
In this retrospective study the authors aimed to investigate the correlation between optical coherence tomography (OCT) findings and visual acuity outcomes after treatment with intravitreal bevacizumab (IVB) injections for age-related macular degeneration (AMD) patients with peripapillary choroidal neovascularisation (PPCNV). Data...
Visual acuity outcomes after cataract surgery in type 2 diabetes (NIDDM): the action to control cardiovascular risk in diabetes (ACCORD) study
This is a retrospective case-control study of 1136 eyes enrolled in the 784 ACCORD patients receiving cataract surgery between 2001-2014. 362 / 1136 eyes had gradable fundus photography for diabetic retinopathy (DR). Seven hundred and sixty-two eyes (67.1%) achieved 20...
Sex hormones in males and females with central serous chorioretinopathy
5 June 2023
| Sofia Rokerya
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EYE - Vitreo-Retinal
This study was aimed to assess the role of sex hormones in male and female patients with central serous chorioretinopathy (CSC), a disease with a pronounced male predilection. Two hundred and six patients, 183 males (mean age 52, median 52,...
Gene therapy: perspectives from young adults with Leber’s congenital amaurosis
5 June 2023
| Ivan Yip
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EYE - Vitreo-Retinal
The authors present their telephone survey data of 10 patients with a mean age of 24.4 years regarding their opinion on gene therapy for their Leber’s congenital amaurosis. Patients were recruited at the Hospital for Sick Children, Toronto. Of the...
A paradigm shift: re-defining success in retinal detachment repair
3 April 2023
| Zhihang Cheng
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EYE - Vitreo-Retinal
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Integrity, Outer retinal folds, Pneumatic retinopexy, Retinal detachment, Retinal displacement, Scleral buckle, Vitrectomy
The authors describe in this review article that functional outcomes vary with surgical technique for retinal detachment repair. Traditional definitions of surgical success have been shifted due to advances in imaging techniques. Assessment of the integrity of retinal reattachment including...
Ocular hypertension following intravitreal steroid injections: a comparative study between triamcinolone-acetonide and dexamethasone-implant
3 April 2023
| Sofia Rokerya
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EYE - Vitreo-Retinal
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Dexamethasone-implant, Glaucoma, Intravitreal steroid-induced ocular hypertension, Risk factors for steroid-induced ocular hypertension, Triamcinolone-acetonide
This was a retrospective observational study of steroid response following 1549 intravitreal steroid (TA and Dex) injections. One thousand and seventy-five eyes of 897 patients were reviewed. Glaucoma patients, glaucoma suspects, uveitis, trauma, and cases with less than one month...
Treatment of diabetic macular edema in vitrectomised eyes – comparison of intravitreal dexamethasone implant and posterior subtenon triamcinolone injection
3 April 2023
| Sofia Rokerya
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EYE - Vitreo-Retinal
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Dexamethasone implant, Diabetic macular edema, Pars plana vitrectomy, Posterior subtenon triamcinolone
This retrospective study was aimed to compare intravitreal dexamethasone implant and posterior subtenon triamcinolone injection (PSTA) in the treatment of diabetic macular edema (DME) in vitrectomised eyes. Sixty-four (48.12%) patients who had received PSTA and 69 (51.88%) patients who had...
